Abstract: 【Abstract】 Generalized pustular psoriasis （GPP） is a rare and life-threatening autoinflammatory disorder. Recent advances in genetics, immunology, and targeted therapies have made its pathogenesis increasingly clear and led to refinements in diagnostic criteria and treatment strategies. Nonetheless, several challenges remain unresolved, including the heterogeneity of clinical phenotypes and therapeutic responses, as well as the prediction and control of disease relapse. Future research will focus on dissecting the immune mechanisms and pivotal inflammatory signaling pathways underlying GPP, identifying novel therapeutic targets, and developing more effective and durable treatment regimens based on research findings.

Key words: Psoriasis, Generalized pustular psoriasis, Pathogenesis, Therapy, Therapeutic targets, Neutrophils