Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (10): 910-913.doi: 10.35541/cjd.20250170

• Expert Commentary • Previous Articles     Next Articles

Focusing on the status, challenges and countermeasures of mpox susceptibility in children

Lu Qinghua1, Yu Dingle1, Ma Xiang2,3, Yin Jun3, Ma Lin4, Yang Yonghong5,6   

  1. 1Department of Respiratory Medicine, Shenzhen Children′s Hospital, Shenzhen 518038, Guangdong, China; 2Department of Respiratory Medicine, Children's Hospital Affiliated to Shandong University, Pediatric Research Institute, Jinan Children's Hospital, Jinan 250022, China; 3Department of Infectious Diseases/Nosocomial Infection Management, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 4Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China; 5Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 6Department of Microbiology and Immunology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
  • Received:2025-04-01 Revised:2025-07-18 Online:2025-09-15 Published:2025-09-30
  • Contact: Yang Yonghong E-mail:yyh628628@sina.com

Abstract: 【Abstract】 Since the global outbreak in 2022, the mpox epidemic has evolved from an African endemic to a public health emergency of international concern. The 2024 mpox outbreak in the Democratic Republic of the Congo caused by the Clade Ⅰb lineage is yet another wake?up call, with markedly higher prevalence and fatality rates observed among children under 15 years of age, thereby presenting new challenges for the children. Therefore, it is necessary to strengthen prevention and control, block mother?to?child transmission routes, and establish innovative models with active community participation to reduce the risk of mpox transmission. In the future, it is urgent to analyze molecular mechanisms underlying the mother?to?child transmission of the virus, develop targeted antiviral drugs, establish a pediatric critical disease scoring system, and incorporate mpox vaccines into the World Health Organization′s expanded programme on immunization.

Key words: Monkeypox, Child, Signs and symptoms, Therapy, Communicable disease control