Abstract: 【Abstract】 Atopic dermatitis （AD） is a chronic inflammatory skin disease in which antigen presentation and T-cell activation, the persistence of memory T cells, and subclinical chronic inflammation are closely associated with disease chronicity, recurrence, and the development of atopic comorbidities. Disease modification aims to alter the natural course of a disease through clinical intervention and to achieve sustained deep remission after treatment discontinuation. In recent years, the introduction of multiple targeted biologic agents has markedly changed the clinical manifestations of AD, as well as its natural disease course and associated comorbidities. This article reviews recent advances in biologic targeted therapies for AD and their disease-modifying value.

Key words: Dermatitis, atopic, Chronic inflammation, Disease modification, Molecular targeted therapy, Immunologically activated cell