Chinese Journal of Dermatology ›› 2023, e20230083.doi: 10.35541/cjd.20230083

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Three-dimensional culture techniques of mesenchymal stem cells and their application in the treatment of skin diseases

Wang Qi, Jian Zhe   

  • Received:2023-02-17 Revised:2023-04-06 Online:2023-01-05 Published:2023-07-21
  • Contact: Jian Zhe
  • Supported by:
    National Natural Science Foundation of China (82173414); Key Projects of Shaanxi Natural Science Basic Research Program (S2023-JC-ZD-0226); Flying Plan of Lingyun Project of Air Force Military Medical University (axjhjz-102)

Abstract: 【Abstract】 Mesenchymal stem cells (MSCs) have regenerative repair and immunoregulatory capabilities. Three-dimensional culture techniques provide a more human-friendly environment for cell living, can effectively promote cell proliferation, differentiation and paracrine capabilities, and improve various biological characteristics of MSCs. This review summarizes three-dimensional culture techniques of MSCs and their application in skin diseases, and provides a reference for the selection of three-dimensional culture methods for MSCs and their clinical application in skin diseases.

Key words: Mesenchymal stem cells, Cell culture techniques, Three-dimensional culture, Skin damage and repair, Photoaging, Autoimmune diseases, Lupus erythematosus, systemic