Chinese Journal of Dermatology ›› 2024, Vol. 57 ›› Issue (1): 78-81.doi: 10.35541/cjd.20210591

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Role of neurogenic inflammatory factors in the pathogenesis of vitiligo

Wang Haoyang, Wang Yidan, Lu Yan    

  1. Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
  • Received:2021-08-16 Revised:2023-06-20 Online:2024-01-15 Published:2024-01-05
  • Contact: Lu Yan
  • Supported by:
    National Natural Science Foundation of China(81872541)

Abstract: 【Abstract】 Vitiligo is an acquired depigmented disease, and neurological factors may play an important role in its pathogenesis. Neurogenic inflammatory factors released by sensory nerves that control the skin can directly or indirectly regulate functions of keratinocytes, melanocytes, Langerhans cells, dermal dendritic cells, mast cells, dermal microvascular endothelial cells and immune cells. This review summarizes roles of several relevant neurogenic inflammatory factors in the occurrence and development of vitiligo, including neuropeptide Y, calcitonin gene-related peptide, catecholamines and nerve growth factor, with a view to providing new ideas for clinical treatment of vitiligo.

Key words: Vitiligo, Neuro secretory systems, Autoimmunity, Psychological and neurological effects