Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (10): 919-921.doi: 10.35541/cjd.20210448

• Reviews • Previous Articles     Next Articles

Mechanisms of pruritus in bullous pemphigoid

Kailibinuer·Abulikemu1, Liang Junqin2   

  1. 1Postgraduate School of Xinjiang Medical University, Urumqi 830054, China; 2Department of Dermatology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research(XJYS1707), Urumqi 830002, China
  • Received:2021-06-11 Revised:2022-03-08 Online:2022-10-15 Published:2022-10-08
  • Contact: Liang Junqin E-mail:zyeemail@163.com
  • Supported by:
    National Natural Science Foundation of China(81960564)

Abstract: 【Abstract】 Pruritus is one of the typical clinical manifestations of bullous pemphigoid (BP). In recent years, researchers have gradually recognized that the histamine-independent itch pathway plays an important role in BP. Eosinophils, basophils, interleukin (IL)-31, IL-4, IL-13, thymic stromal lymphopoietin, periostin and substance P are all closely related to the occurrence of pruritus in BP. This review mainly elaborates research progress in mechanisms related to pruritus in BP.

Key words: Pemphigoid, bullous, Pruritus, Interleukin-4, Eosinophils, Basophils, Interleukin-31