Abstract: 【Abstract】 Objective To evaluate efficacy and safety of dupilumab in the treatment of atopic dermatitis （AD）. Methods A retrospective study was conducted among patients with AD who showed poor response to topical agents and then received standardized injections of dupilumab for 16 weeks in Department of Dermatology, Peking University First Hospital from June 1, 2020 to September 1, 2021. Basic information on the patients was collected, so were the Investigator′s Global Assessment （IGA） , Eczema Area and Severity Index （EASI） , Itch Numeric Rating Scale （NRS） , Dermatology Life Quality Index （DLQI） , and Patient-Oriented Eczema Measure （POEM） scores recorded before and at weeks 2, 4, 8, 12, and 16 during treatment. Adverse reactions were recorded during treatment. Wilcoxon rank sum test was used to compare the scores of all patients at the end of follow-up with those before treatment. Results A total of 57 patients were enrolled in the study, and all completed 16-week injections and follow-up. At week 16, the patients′ IGA, EASI, NRS, DLQI, and POEM scores significantly decreased from 4.0 （4.0, 5.0）, 30.0 （17.2, 36.0）, 9.0 （7.0, 10.0）, 15.0 （11.5, 20.5）, and 19.0 （15.5, 23.0） points respectively at baseline to 1.0 （1.0, 1.0）, 4.0 （1.6, 7.3）, 1.0 （0.0, 1.0）, 3.0 （1.0, 4.0）, and 4.0 （2.0, 4.0） points respectively （Z = 6.65, 6.57, 6.59, 6.57, and 6.57 respectively, all P < 0.001）. All the 5 scale scores showed a continuous downward trend within 16 weeks after the start of dupilumab treatment. During the follow-up period, no serious adverse reaction was observed, and only two patients developed conjunctivitis. Conclusion Dupilumab shows marked efficacy in the treatment of AD, with favorable safety.

Key words: Dermatitis, atopic, Interleukin-4, Interleukin-13, Biological agents, Therapy, Drug toxicity, Dupilumab