Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (5): 460-462.doi: 10.35541/cjd.20200235

• Reviews • Previous Articles    

Tranexamic acid for the treatment of melasma

Hu Yebei1, Song Xiuzu2   

  1. 1Department of Dermatology, The Third People′s Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China; 2Department of Dermatology, The Third People′s Hospital of Hangzhou, Hangzhou 310009, China 
  • Received:2020-03-11 Revised:2020-09-03 Online:2022-05-15 Published:2022-04-29
  • Contact: Song Xiuzu E-mail:songxiuzu@sina.com
  • Supported by:
    National Natural Science Foundation of China （81872517）; Zhejiang Basic Public Welfare Research Project（LGF18H110001）; Hangzhou Medical Key Specialized Disease Project（20130733Q24）

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Abstract: 【Abstract】 Tranexamic acid can treat melasma through multiple steps, such as inhibiting dermal angiogenesis, reducing the number of mast cells and inhibiting their activity, reducing damage to the basement membrane zone, inhibiting melanin synthesis and transport in the epidermis, and promoting the recovery of skin barrier function. This review summarizes the mechanism and efficacy of tranexamic acid in the treatment of melasma, providing more evidence for its clinical application.

Key words: Melasma, Drug therapy, Tranexamic acid, Treatment outcome