Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (1): 72-75.doi: 10.35541/cjd.20191176

• Reviews • Previous Articles     Next Articles

Biological agents in the treatment of moderate to severe plaque psoriasis and psoriatic arthritis

Gao Rong1, Zhang Lan2, Li Zhengxiao1   

  1. 1Department of Dermatology, The Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China; 2Department of Dermatology, East Hospital of the First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710089, China
  • Received:2019-12-23 Revised:2021-06-17 Online:2022-01-15 Published:2021-12-31
  • Contact: Li Zhengxiao E-mail:lizhengxiao1979@163.com

Abstract: 【Abstract】 Psoriasis is an immune-mediated chronic recurrent inflammatory disease, and biological agents targeting cytokines and their receptors involved in its pathogenesis have become an increasingly important option for its treatment in recent years. With the successive appearance of biological agents such as secukinumab and ustekinumab on the market in China, the use of biologics will become increasingly common in the treatment of psoriasis. This review summarizes the efficacy of different biological agents and individualized drug selection in the treatment of moderate to severe plaque psoriasis and psoriatic arthritis, with a view to providing a reference for physicians in clinical practice.

Key words: Psoriasis, Biological agents, Tumor necrosis factor?alpha, Interleukin?17, Interleukins, Treatment outcome, Moderate to severe plaque psoriasis