上皮源性细胞因子白细胞介素33、白细胞介素25和胸腺基质淋巴细胞生成素在特应性皮炎发病机制中的作用

doi:10.35541/cjd.20200274

Abstract

Abstract: 【Abstract】 Epidermal barrier defects and immune abnormalities are the main pathophysiological changes in the development of atopic dermatitis （AD）. Skin keratinocytes can release a variety of inflammatory factors and mediators under the treatment with various harmful factors. Three epithelium?derived cytokines interleukin （IL）-33, IL-25 and thymic stromal lymphopoietin are considered to be effective inducers of Th2 immune response in skin or mucosal barrier, which can activate immune cells, cause the secretion of Th2 cytokines, enhance the Th2 immune response, and participate in the occurrence and development of AD. This review focuses on the role of the above 3 epithelium?derived cytokines in the pathogenesis of AD.

Key words: Dermatitis, atopic, Interleukins, Interleukin-33, Interleukin-25, Thymic stromal lymphopoietin

Lu Xiaoyun, Zhang Zengyunou, Xiao Fengli. Role of epithelium-derived cytokines interleukin-33, interleukin-25 and thymic stromal lymphopoietin in the pathogenesis of atopic dermatitis[J]. Chinese Journal of Dermatology, 2022, 55(6): 548-551.doi:10.35541/cjd.20200274

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Role of epithelium-derived cytokines interleukin-33, interleukin-25 and thymic stromal lymphopoietin in the pathogenesis of atopic dermatitis

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