中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (10): 731-732.

• 研究报道 • 上一篇    下一篇

银屑病患者粒-单核巨噬细胞集落刺激因子表达的研究

谢欣1,柴立1,2,周毅成2,3,安娜1,2,田静4   

  1. 1. 黑龙江省皮肤病防治研究所
    2.
    3. 哈尔滨医科大学附属第一医院皮肤科
    4. 哈尔滨医科大学第一临床医学院
  • 收稿日期:2010-12-06 修回日期:2011-01-08 出版日期:2011-10-15 发布日期:2011-09-30
  • 通讯作者: 谢欣 E-mail:gongth@126.com

Expression of granulocyte macrophage-colony stimulating factor in patients with psoriasis

  • Received:2010-12-06 Revised:2011-01-08 Online:2011-10-15 Published:2011-09-30
  • Contact: xin XIE E-mail:gongth@126.com

PDF

35

赞

摘要：

目的 探讨脓疱性银屑病和寻常性银屑病患者皮损组织及外周血粒-单核巨噬细胞集落刺激因子（GM-CSF）表达的变化。方法 免疫组化法和双抗体夹心酶联免疫吸附法（ELISA）分别检测脓疱性银屑病和寻常性银屑病患者皮损组织和外周血中GM-CSF表达水平，并与正常人进行比较。结果 与正常人对照组相比，脓疱性银屑病组和寻常性银屑病组皮损组织中GM-CSF表达均增高（P < 0.01），且脓疱性银屑病组皮损组织中GM-CSF表达高于寻常性银屑病组（P < 0.01）。与正常人对照组相比，脓疱性银屑病组和寻常性银屑病组外周血中GM-CSF含量均升高（P < 0.01），且脓疱性银屑病组外周血中GM-CSF水平高于寻常性银屑病组（P < 0.01）。结论 GM-CSF可能参与银屑病的发病。

关键词: 银屑病

Abstract:

Objective To investigate the expression of granulocyte macrophage-colony stimulating factor （GM-CSF） in skin lesions and sera of patients with pustular psoriasis and psoriasis vulgaris. Methods Tissue specimens were obtained from the lesions of 15 patients with pustular psoriasis, 15 patients with psoriasis vulgaris and 15 normal human controls. Immunohistochemistry and dual antibody sandwich enzyme-linked immunosorbent assay（ELISA） were carried out to detect the levels of GM-CSF in the tissue and serum specimens from the patients and normal human controls, respectively. Results Significantly higher levels of GM-CSF were observed in the tissue and serum specimens from patients with pustular psoriasis and psoriasis vulgaris compared with the normal controls（all P < 0.01）, as well as in those from the patients with pustular psoriasis compared with the patients with psoriasis vulgaris （both P < 0.01）. Conclusion GM-CSF may be involved in the pathogenesis of psoriasis.

Key words: psoriasis

中图分类号: 

  • R 758. 63