中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (10): 729-730.

• 研究报道 • 上一篇    下一篇

Q开关激光多疗程治疗太田痣无效二例

胡玲玲1,宋为民2,沈静3,郑涵4,陈俊帆4   

  1. 1. 浙江省杭州市第三人民医院
    2. 杭州市第三人民医院，安徽医科大学附属杭州市第三人民医院
    3. 安徽医科大学附属杭州市第三人民医院皮肤科
    4. 杭州市第三人民医院皮肤科
  • 收稿日期:2010-12-17 修回日期:2011-02-10 出版日期:2011-10-15 发布日期:2011-09-30
  • 通讯作者: 宋为民 E-mail:doctorsong@126.com

Nevus of Ota resistant to multiple sessions of Q-switched laser treatment: two case report

  • Received:2010-12-17 Revised:2011-02-10 Online:2011-10-15 Published:2011-09-30
  • Contact: weimin song E-mail:doctorsong@126.com

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摘要：

报道2例激光治疗多次无效的太田痣。患者均为女性，均在出生后数月发病，累及左侧面部，皮损表现为颧部、面颊部灰褐色至褐青色斑片，巩膜无蓝染。1例怀孕期斑片扩展至左耳后及左颈后。组织病理显示真皮深层及皮下脂肪组织间散在分布黑素细胞及噬黑素细胞，胶原纤维明显增生。免疫组化CD34标记血管内皮细胞分布无异常。对一般用于太田痣的激光治疗反应差。Q开关翠绿宝石激光（波长755 nm）和或Q开关Nd:YAG激光（波长1064 nm）累计治疗10余次几乎无效（1例治疗12次，1例治疗13次），且激光即刻反应特殊，即使高能量多次重复照射，皮疹处均无紫癜或渗血，而周围正常皮肤较低能量下即可见明显的紫癜和渗血。

关键词: 疗效

Abstract:

Two cases of nevus of Ota resistant to multiple sessions of Q-switched laser treatment are reported. Both of the patients were females, who developed beige or blue patches on the left side of the face （zygomatic region, cheek） several months after birth. No conjunctiva or sclera was involved. The lesions spread to the left retroauricular region and posterior neck during pregnancy in one patient. Histopathological examination of the lesions showed scattered melanocytes and melanophages in lower dermis and subcutaneous adipose tissue as well as apparent proliferation of collagen. Immunostaining for CD34 showed no abnormality in the distribution of vascular endothelial cells in these tissues. No obvious improvement was observed in either of the patient after more than 10 sessions （12 sessions in 1 case, and 13 sessions in the other case） of treatments with Q-switched alexandrite （755 nm） or Q-switched Nd:YAG laser （1064 nm）. The immediate response of lesions to laser irradiation was unusual. Purpura or errhysis was absent in the lesions after repetitive irradiation with high-energy laser, but both were visible in the adjacent normal skin even after irradiation with low-energy laser.

Key words: effect