长链非编码RNA在皮肤良恶性增生性疾病中的研究进展

doi:10.35541/cjd.20210118

中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (11): 1080-1084.doi: 10.35541/cjd.20210118

• 综述 • 上一篇

长链非编码RNA在皮肤良恶性增生性疾病中的研究进展

杨霄曾彦超何黎吴文娟

昆明医科大学第一附属医院皮肤科云南省皮肤病医院，昆明 650032

收稿日期:2021-02-02 修回日期:2021-11-07 发布日期:2023-11-03
通讯作者: 吴文娟 E-mail:wuwj1021@126.com
基金资助:
国家自然科学基金（81760559）；云南省科技人才和平台计划项目（2017HB044）

Long non-coding RNAs in benign and malignant proliferative skin diseases

Yang Xiao, Zeng Yanchao, He Li, Wu Wenjuan

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming 650032, China

Received:2021-02-02 Revised:2021-11-07 Published:2023-11-03
Contact: Wu Wenjuan E-mail:wuwj1021@126.com
Supported by:
National Natural Science Foundation of China（81760559）; Yunnan Science and Technology Leading Talents Project （2017HB044）

摘要/Abstract

摘要： 【摘要】长链非编码RNA（lncRNA）是一类长度大于200 nt且绝大多数不编码产生蛋白质的分子。研究发现lncRNA可在表观遗传、转录、转录后水平调控基因表达，影响肿瘤细胞的增殖、迁移和浸润等过程，参与瘢痕疙瘩、血管瘤、鳞状细胞癌、黑素瘤等皮肤良、恶性增生性疾病的发生和发展。本文综述lncRNA在皮肤良、恶性增生性疾病发病机制中的研究进展。

关键词: 皮肤肿瘤, 基因表达调控, RNA, 未翻译, 长链非编码RNA

Abstract: 【Abstract】 Long non-coding RNAs （lncRNAs） are a group of non-coding RNAs with the length of over 200 nucleotides. Recently, studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels, affect the proliferation, migration, and infiltration of tumor cells, and participate in the occurrence and development of benign and malignant proliferative skin diseases, such as keloids, hemangioma, squamous cell carcinoma and melanoma. This review summarizes roles of lncRNAs in the pathogenesis of benign and malignant proliferative skin diseases.

Key words: Skin neoplasms, Gene expression regulation, RNA, noncoding, Long non-coding RNA

杨霄曾彦超何黎吴文娟. 长链非编码RNA在皮肤良恶性增生性疾病中的研究进展[J]. 中华皮肤科杂志, 2023,56(11):1080-1084. doi:10.35541/cjd.20210118

Yang Xiao, Zeng Yanchao, He Li, Wu Wenjuan. Long non-coding RNAs in benign and malignant proliferative skin diseases[J]. Chinese Journal of Dermatology, 2023, 56(11): 1080-1084.doi:10.35541/cjd.20210118

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长链非编码RNA在皮肤良恶性增生性疾病中的研究进展

Long non-coding RNAs in benign and malignant proliferative skin diseases

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