长链非编码RNA介导的竞争性内源RNA调控网络在瘢痕疙瘩中的研究进展

doi:10.35541/cjd.20210471

中华皮肤科杂志 ›› 2023, e20210471.doi: 10.35541/cjd.20210471

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长链非编码RNA介导的竞争性内源RNA调控网络在瘢痕疙瘩中的研究进展

朱学娥段曼曼丁媛

新疆维吾尔自治区人民医院皮肤性病科新疆皮肤病研究重点实验室（XJYS1707），乌鲁木齐 830001

收稿日期:2021-06-25 修回日期:2022-04-29 发布日期:2023-02-08
通讯作者: 丁媛 E-mail:dydyuan@126.com
基金资助:
新疆维吾尔自治区自然科学基金资助项目（2019D01C134、2021D01C147）

Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids

Zhu Xue′e, Duan Manman, Ding Yuan

Department of Dermatology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research （XJYS1707）

Received:2021-06-25 Revised:2022-04-29 Published:2023-02-08
Contact: Ding Yuan E-mail:dydyuan@126.com
Supported by:
Natural Science Foundation of Xinjiang Uygur Autonomous Region of China（2019D01C134、2021D01C147）

摘要/Abstract

摘要： 【摘要】长链非编码RNA（lncRNA）在瘢痕疙瘩中异常表达，部分lncRNA可与miRNA相互作用，作为竞争性内源RNA（ceRNA）来调节下游信使RNA表达，这些RNA分子相互关联形成复杂的ceRNA调节网络，在瘢痕疙瘩的发生和发展中发挥重要作用。本文综述lncRNA及其介导的ceRNA调控网络与瘢痕疙瘩的关系，以进一步探索瘢痕疙瘩的发病机制。

关键词: 瘢痕疙瘩, 基因调控网络, 微RNA, 长链非编码RNA, 竞争性内源RNA

Abstract: 【Abstract】 Long non-coding RNAs （lncRNAs） are aberrantly expressed in keloids, and some lncRNAs can interact with miRNAs and act as competitive endogenous RNAs （ceRNAs） to regulate downstream mRNA expression. These RNA molecules are interconnected to form a complex ceRNA regulatory network, playing an important role in the occurrence and development of keloids. This review summarizes the relationship between lncRNAs and their mediated ceRNA regulatory networks and keloids, in order to further explore the pathogenesis of keloids.

Key words: Keloid, Gene regulatory networks, MicroRNAs, Long non-coding RNA, Competitive endogenous RNA

朱学娥段曼曼丁媛. 长链非编码RNA介导的竞争性内源RNA调控网络在瘢痕疙瘩中的研究进展[J]. 中华皮肤科杂志, 2023,e20210471. doi:10.35541/cjd.20210471

Zhu Xue′e, Duan Manman, Ding Yuan. Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids[J]. Chinese Journal of Dermatology,2023,e20210471. doi:10.35541/cjd.20210471

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长链非编码RNA介导的竞争性内源RNA调控网络在瘢痕疙瘩中的研究进展

Long non-coding RNA-mediated competitive endogenous RNA regulatory network in keloids

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