节段型白癜风的发病机制及治疗进展

doi:10.35541/cjd.20250500

中华皮肤科杂志 ›› 2026, e20250500.doi: 10.35541/cjd.20250500

节段型白癜风的发病机制及治疗进展

方钦一沈乃婷徐中奕项蕾红张成锋

复旦大学附属华山医院皮肤科，上海 200040

收稿日期:2025-09-17 修回日期:2026-01-19 发布日期:2026-03-26
通讯作者: 张成锋
基金资助:
国家自然科学基金（82473523，82373498）；国家重点研发计划（2023YFC2509001）

Pathogenesis and treatment of segmental vitiligo

Fang Qinyi, Shen Naiting, Xu Zhongyi, Xiang Leihong, Zhang Chengfeng

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2025-09-17 Revised:2026-01-19 Published:2026-03-26
Contact: Zhang Chengfeng
Supported by:
National Natural Science Foundation of China （82473523, 82373498）; National Key Research and Development Program of China （2023YFC2509001）

摘要/Abstract

摘要： 【摘要】节段型白癜风单侧累及的关键病理机制尚未阐明，其与非节段型白癜风的本质差异亦未明确，导致目前仍缺乏针对性治疗策略。本文系统总结了节段型白癜风的临床特征、发病机制及诊疗进展，并探讨了未来研究方向。

关键词: 白癜风, 黑素细胞, 镶嵌现象, 节段型白癜风, 神经免疫

Abstract: 【Abstract】 The key pathological mechanisms underlying the unilateral involvement in segmental vitiligo remain poorly elucidated, and its fundamental distinctions from non-segmental vitiligo have not been clearly defined, resulting in a lack of targeted therapeutic strategies for segmental vitiligo. This review systematically summarizes the clinical features, pathogenesis, and diagnostic and therapeutic advances in segmental vitiligo, and discusses promising directions for future research.

Key words: Vitiligo, Melanocytes, Mosaicism, Segmental vitiligo, Neuroimmunity

方钦一沈乃婷徐中奕项蕾红张成锋. 节段型白癜风的发病机制及治疗进展[J]. 中华皮肤科杂志, 2026,e20250500. doi:10.35541/cjd.20250500

Fang Qinyi, Shen Naiting, Xu Zhongyi, Xiang Leihong, Zhang Chengfeng. Pathogenesis and treatment of segmental vitiligo[J]. Chinese Journal of Dermatology,2026,e20250500. doi:10.35541/cjd.20250500

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节段型白癜风的发病机制及治疗进展

Pathogenesis and treatment of segmental vitiligo

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