干细胞在头皮衰老中的作用及相关治疗策略

doi:10.35541/cjd.20240619

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (7): 671-675.doi: 10.35541/cjd.20240619

干细胞在头皮衰老中的作用及相关治疗策略

丁炜蕴¹ 林尽染¹ 刘庆梅¹ 张悦¹ 杨凯¹ 倪春雅² 吴文育^1，2

¹复旦大学附属华山医院皮肤科上海市皮肤病研究所，上海 200040；²上海市静安区中心医院皮肤科，上海 200040

收稿日期:2024-11-14 修回日期:2025-05-20 发布日期:2025-07-03
通讯作者: 吴文育 E-mail:wenyu_wu@fudan.edu.cn
基金资助:
上海申康医院发展中心项目（SHDC22022302）；上海市重中之重研究中心建设项目（2023ZZ02018）；静安区学科建设项目培育学科（2024PY01）

Role of stem cells in scalp aging and related therapeutic strategies

Ding Weiyun¹, Lin Jinran¹, Liu Qingmei¹, Zhang Yue¹, Yang Kai¹, Ni Chunya², Wu Wenyu^1,2

¹Department of Dermatology,Huashan Hospital,Shanghai Institute of Dermatology,Fudan University,Shanghai 200040, China; ²Department of Dermatology, Jing'an District Central Hospital, Shanghai 200040, China

Received:2024-11-14 Revised:2025-05-20 Published:2025-07-03
Contact: Wu Wenyu E-mail:wenyu_wu@fudan.edu.cn
Supported by:
Clinical Research Plan of Shanghai Hospital Development Center Foundation （SHDC22022302）; Key Specialty Research Centre of Shanghai Health Commission （2023ZZ02018）; Jing'an District Discipline Development Education Program （2024PY01）

摘要/Abstract

摘要： 【摘要】毛囊干细胞（HFSC）的变化可影响头皮衰老及毛发生长。随着年龄增长，HFSC的静止状态、自我更新和分化能力下降，导致毛发生长周期缩短甚至脱发。本文综述脱发背后多因素相互作用的最新研究成果，包括HFSC静止状态的调控机制、衰老对其功能的影响以及干细胞微环境的老化，干细胞与毛干的关系以及干细胞在头皮衰老中的作用机制（包括信号通路的变化、染色质重塑、表观遗传调控等），以及基于干细胞的治疗方法如使用干细胞或其分泌的外泌体，调节干细胞微环境以及药物治疗等策略。

关键词: 毛囊, 衰老, 秃发, 头皮, 毛发再生, 表观遗传学, 细胞凋亡, 外泌体

Abstract: 【Abstract】 Changes in hair follicle stem cells （HFSCs） can affect scalp aging and hair growth. With increasing age, HFSCs exhibit a decrease in quiescence maintenance and self-renewal capacity, as well as differentiation potential, leading to shortened hair growth cycles and even hair loss. This review summarizes recent research advances in the multifactorial interactions underlying hair loss, including the regulatory mechanisms of HFSC quiescence, the impact of aging on HFSC function, and aging of the stem cell microenvironment. Additionally, this review discusses the relationship between stem cells and hair shafts, and the mechanisms of action of stem cells in scalp aging, including alterations in signaling pathways, chromatin remodeling, and epigenetic regulation, etc. Furthermore, stem cell-based therapeutic strategies are summarized, such as the use of stem cells or their secreting exosomes, modulation of the stem cell microenvironment, and pharmacological interventions.

Key words: Hair follicle, Aging, Alopecia, Scalp, Hair regeneration, Epigenetics, Apoptosis, Exosomes

丁炜蕴林尽染刘庆梅张悦杨凯倪春雅吴文育. 干细胞在头皮衰老中的作用及相关治疗策略[J]. 中华皮肤科杂志, 2025,58(7):671-675. doi:10.35541/cjd.20240619

Ding Weiyun, Lin Jinran, Liu Qingmei, Zhang Yue, Yang Kai, Ni Chunya, Wu Wenyu, . Role of stem cells in scalp aging and related therapeutic strategies[J]. Chinese Journal of Dermatology, 2025, 58(7): 671-675.doi:10.35541/cjd.20240619

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干细胞在头皮衰老中的作用及相关治疗策略

Role of stem cells in scalp aging and related therapeutic strategies

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