中华皮肤科杂志 ›› 2024, Vol. 57 ›› Issue (5): 450-454.doi: 10.35541/cjd.20240038

• 论著 • 上一篇    下一篇

2018—2023年中国生殖道沙眼衣原体感染流行趋势及时空分布特征

简慧1    陈泽伟1    岳晓丽2    李婧2    张家晖2    龚向东2   

  1. 1北京协和医学院  中国医学科学院  皮肤病医院  皮肤病研究所，南京  210042；2中国医学科学院  北京协和医学院皮肤病医院  中国疾病预防控制中心性病控制中心流行病学室，南京  210042
  • 收稿日期:2024-01-22 修回日期:2024-03-06 发布日期:2024-04-30
  • 通讯作者: 龚向东 E-mail:gxdchina@163.com
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目（CIFMS-2021-I2M-1-001）

Epidemic trends and spatiotemporal distribution characteristics of genital Chlamydia trachomatis infection in China from 2018 to 2023

Jian Hui1, Chen Zewei1, Yue Xiaoli2, Li Jing2, Zhang Jiahui2, Gong Xiangdong2   

  1. 1Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China; 2Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Division of Sexually Transmitted Disease Epidemiology, National Center for STD Control of Chinese Center for Disease Control and Prevention, Nanjing 210042, China
  • Received:2024-01-22 Revised:2024-03-06 Published:2024-04-30
  • Contact: Gong Xiangdong E-mail:gxdchina@163.com
  • Supported by:
    CAMS Innovation Fund for Medical Sciences （CIFMS-2021-I2M-1-001）

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摘要： 【摘要】 目的 分析我国近年生殖道沙眼衣原体感染的流行趋势和时空分布特征，为精准防控提供参考。方法 通过中国疾病预防控制信息系统传染病监测系统收集2018—2023年全国（不含港澳台地区）生殖道沙眼衣原体感染疫情报告数据，应用Joinpoint 4.9.1软件进行时间趋势分析，使用ArcGIS 10.5软件以县区为地理单位进行全局和局部空间自相关分析，应用SaTScan 10.1.2软件进行时空扫描分析。结果 2018—2023年全国生殖道沙眼衣原体感染报告发病率从12.66/10万轻度下降至12.45/10万，年均变化比例为-1.42%，下降趋势无统计学意义（t = -1.14，P = 0.318）。全国县区级生殖道沙眼衣原体感染报告发病率呈显著的全局空间正自相关，全局Moran指数为0.68 ~ 0.74（均P < 0.001）；全局G 系数标准化统计量Z（G）均 > 1.96，聚集模式为高值聚集。局部空间自相关分析显示，华南和华东部分地区是生殖道沙眼衣原体感染发生的热点地区。时空扫描分析共探测到38个有统计学意义的时空聚集区，主要分布在华南及华东地区，与热点地区一致。结论 2018—2023年我国生殖道沙眼衣原体感染报告发病率轻度下降，疫情存在时空聚集特征，需要针对热点地区和时空聚集区开展精准防控工作。

关键词: 沙眼衣原体, 发病率, 生殖道, 流行趋势, 时空分析

Abstract: 【Abstract】 Objective To investigate the epidemic trends and spatiotemporal distribution characteristics of genital Chlamydia trachomatis infection in China in recent years, and to provide a reference for its precise prevention and control. Methods Data on reported cases of genital Chlamydia trachomatis infection in China （not including Hongkong, Macau and Taiwan regions of China） were collected through the Infectious Diseases Surveillance System of Chinese Disease Prevention and Control Information System from 2018 to 2023. The trend in the incidence rate was analyzed using the Joinpoint 4.9.1 software. Global and local spatial autocorrelation analyses at the county level were conducted using the ArcGIS 10.5 software. Spatiotemporal scanning analysis was carried out with the SaTScan 10.1.2 software. Results The reported incidence rates of genital Chlamydia trachomatis infection slightly declined from 12.66 per 100 000 in 2018 to 12.45 per 100 000 in 2023, with an average annual percent change of -1.42%, which was not statistically significant （t = -1.14, P = 0.318）. The reported incidence rates of genital Chlamydia trachomatis infection at the county level in China showed a significant positive global spatial autocorrelation, with the global Moran′s indices ranging from 0.68 to 0.74 （all P < 0.001）; the standardized statistic Z （G） values for the Getis-Ord general G were all greater than 1.96, indicating a high-value clustering pattern. Local spatial autocorrelation analysis revealed that hotspot areas were predominantly located in southern and eastern China. In the spatiotemporal scanning analysis, 38 statistically significant spatiotemporal clusters were identified, mainly distributed in southern and eastern China and consistent with the hotspot areas. Conclusions From 2018 to 2023, the reported incidence rates of genital Chlamydia trachomatis infection showed a slight decline, and the epidemic exhibited spatiotemporal clustering characteristics in China. Targeted prevention and control measures need to be implemented in hotspot areas and spatiotemporal clusters.

Key words: Chlamydia trachomatis, Incidence, Genital tract, Epidemic trend, Spatiotemporal analysis

引用本文

简慧 陈泽伟 岳晓丽 李婧 张家晖 龚向东. 2018—2023年中国生殖道沙眼衣原体感染流行趋势及时空分布特征[J]. 中华皮肤科杂志, 2024,57(5):450-454. doi:10.35541/cjd.20240038

Jian Hui, Chen Zewei, Yue Xiaoli, Li Jing, Zhang Jiahui, Gong Xiangdong. Epidemic trends and spatiotemporal distribution characteristics of genital Chlamydia trachomatis infection in China from 2018 to 2023[J]. Chinese Journal of Dermatology, 2024, 57(5): 450-454.doi:10.35541/cjd.20240038