中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (5): 350-353.doi: 10.3760/cma.j.issn.0412-4030.2019.05.016
胡煜 陈敏 顾恒
收稿日期:
2018-04-20
修回日期:
2019-01-04
出版日期:
2019-05-15
发布日期:
2019-04-30
通讯作者:
顾恒
E-mail:guheng@aliyun.com
基金资助:
Hu Yu, Chen Min, Gu Heng
Received:
2018-04-20
Revised:
2019-01-04
Online:
2019-05-15
Published:
2019-04-30
Contact:
Gu Heng
E-mail:guheng@aliyun.com
Supported by:
摘要: 【摘要】 银屑病是一种常见的慢性炎症性皮肤病,目前普遍认为该病是在多基因遗传背景下主要由T细胞介导的免疫异常性疾病。近年研究发现,microRNA和lncRNA能够参与多种炎症免疫性疾病的发生发展过程。已证实microRNA和lncRNA能够通过调控角质形成细胞增殖与分化、炎症因子释放以及血管形成等功能参与银屑病的发病过程。本文综述microRNA和lncRNA在银屑病中的研究进展。
胡煜 陈敏 顾恒. microRNA和lncRNA在银屑病中的研究进展[J]. 中华皮肤科杂志, 2019, 52(5): 350-353.
Hu Yu, Chen Min, Gu Heng. MicroRNA and lncRNA in psoriasis[J]. Chinese Journal of Dermatology, 2019, 52(5): 350-353.
[1] | Nestle FO, Kaplan DH, Barker J. Psoriasis[J]. N Engl J Med, 2009,361(5):496⁃509. doi: 10.1056/NEJMra0804595. |
[2] | Wang J, Song YX, Wang ZN. Non⁃coding RNAs in gastric cancer[J]. Gene, 2015,560(1):1⁃8. doi: 10.1016/j.gene.2015.02. 004. |
[3] | Deng X, Su Y, Wu H, et al. The role of microRNAs in autoimmune diseases with skin involvement[J]. Scand J Immunol, 2015,81(3):153⁃165. doi: 10.1111/sji.12261. |
[4] | Sonkoly E, Wei T, Janson PC, et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?[J/OL]. PLoS One, 2007,2(7):e610. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 1905940/. doi: 10.1371/journal.pone.0000610. |
[5] | Xu Y, Ji Y, Lan X, et al. miR⁃203 contributes to IL⁃17⁃induced VEGF secretion by targeting SOCS3 in keratinocytes[J]. Mol Med Rep, 2017,16(6):8989⁃8996. doi: 10.3892/mmr.2017.7759. |
[6] | Primo MN, Bak RO, Schibler B, et al. Regulation of pro⁃inflammatory cytokines TNFα and IL24 by microRNA⁃203 in primary keratinocytes[J]. Cytokine, 2012,60(3):741⁃748. doi: 10.1016/j.cyto.2012.07.031. |
[7] | Wei T, Xu N, Meisgen F, et al. Interleukin⁃8 is regulated by miR⁃203 at the posttranscriptional level in primary human keratinocytes[J/OL]. Eur J Dermatol, 2013. [2018⁃04⁃02]. https://www.jle.com/fr/revues/ejd/e⁃docs/interleukin_8_is_regulated_by_mir_203_at_the_posttranscriptional_level_in_primary_human_keratinocytes_296259/article.phtml. doi: 10.1684/ejd.2013.1997. |
[8] | Meisgen F, Xu Landén N, Wang A, et al. MiR⁃146a negatively regulates TLR2⁃induced inflammatory responses in keratino⁃cytes[J]. J Invest Dermatol, 2014,134(7):1931⁃1940. doi: 10. 1038/jid.2014.89. |
[9] | Hermann H, Runnel T, Aab A, et al. MiR⁃146b probably assists miRNA⁃146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis[J]. J Invest Dermatol, 2017,137(9):1945⁃1954. doi: 10.1016/j.jid.2017.05.012. |
[10] | Srivastava A, Nikamo P, Lohcharoenkal W, et al. MicroRNA⁃146a suppresses IL⁃17⁃mediated skin inflammation and is genetically associated with psoriasis[J]. J Allergy Clin Immunol, 2017,139(2):550⁃561. doi: 10.1016/j.jaci.2016.07.025. |
[11] | Meisgen F, Xu N, Wei T, et al. MiR⁃21 is up⁃regulated in psoriasis and suppresses T cell apoptosis[J]. Exp Dermatol, 2012,21(4):312⁃314. doi: 10.1111/j.1600⁃0625.2012.01462.x. |
[12] | Guinea⁃Viniegra J, Jiménez M, Schonthaler HB, et al. Targeting miR⁃21 to treat psoriasis[J]. Sci Transl Med, 2014,6(225):225re1. doi: 10.1126/scitranslmed.3008089. |
[13] | Xu N, Meisgen F, Butler LM, et al. MicroRNA⁃31 is over⁃expressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40[J]. J Immunol, 2013,190(2):678⁃688. doi: 10.4049/jimmunol.1202695. |
[14] | Yan S, Xu Z, Lou F, et al. NF⁃κB⁃induced microRNA⁃31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis[J]. Nat Commun, 2015,6:7652. doi: 10.1038/ncomms8652. |
[15] | Borska L, Andrys C, Chmelarova M, et al. Roles of miR⁃31 and endothelin⁃1 in psoriasis vulgaris: pathophysiological functions and potential biomarkers[J]. Physiol Res, 2017,66(6):987⁃992. |
[16] | Xu L, Leng H, Shi X, et al. MiR⁃155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis[J]. Biomed Pharmacother, 2017,90:524⁃530. doi: 10. 1016/j.biopha.2017.03.105. |
[17] | Hou RX, Liu RF, Zhao XC, et al. Increased miR⁃155⁃5p in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA profile by microarray[J]. Genet Mol Res, 2016,15(3). doi: 10.4238/gmr. 15038631. |
[18] | Xu N, Brodin P, Wei T, et al. MiR⁃125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2[J]. J Invest Dermatol, 2011,131(7):1521⁃1529. doi: 10.1038/jid.2011.55. |
[19] | Wei T, Folkersen L, Biskup E, et al. Ubiquitin⁃specific peptidase 2 as a potential link between microRNA⁃125b and psoriasis[J]. Br J Dermatol, 2017,176(3):723⁃731. doi: 10.1111/bjd.14916. |
[20] | Jiang M, Sun Z, Dang E, et al. TGFβ/SMAD/microRNA⁃486⁃3p signaling axis mediates keratin 17 and keratinocyte hyperproliferation in psoriasis[J]. J Invest Dermatol, 2017,137(10):2177⁃2186. doi: 10.1016/j.jid.2017.06.005. |
[21] | Ichihara A, Jinnin M, Yamane K, et al. microRNA⁃mediated keratinocyte hyperproliferation in psoriasis vulgaris[J]. Br J Dermatol, 2011,165(5):1003⁃1010. doi: 10.1111/j.1365⁃2133. 2011.10497.x. |
[22] | Chowdhari S, Sardana K, Saini N. miR⁃4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling[J]. Biochim Biophys Acta Mol Basis Dis, 2017,1863(12):3142⁃3152. doi: 10.1016/j.bbadis.2017.08.014. |
[23] | St Laurent G, Wahlestedt C, Kapranov P. The Landscape of long noncoding RNA classification[J]. Trends Genet, 2015,31(5):239⁃251. doi: 10.1016/j.tig.2015.03.007. |
[24] | Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs[J]. Mol Cell, 2011,43(6):904⁃914. doi: 10.1016/j.molcel. 2011.08.018. |
[25] | Tsoi LC, Iyer MK, Stuart PE, et al. Analysis of long non⁃coding RNAs highlights tissue⁃specific patterns and epigenetic profiles in normal and psoriatic skin[J]. Genome Biol, 2015,16:24. doi: 10.1186/s13059⁃014⁃0570⁃4. |
[26] | Ahn R, Gupta R, Lai K, et al. Network analysis of psoriasis reveals biological pathways and roles for coding and long non⁃coding RNAs[J]. BMC Genomics, 2016,17(1):841. doi: 10.1186/ s12864⁃016⁃3188⁃y. |
[27] | Gupta R, Ahn R, Lai K, et al. Landscape of long noncoding RNAs in psoriatic and healthy skin[J]. J Invest Dermatol, 2016,136(3):603⁃609. doi: 10.1016/j.jid.2015.12.009. |
[28] | Szegedi K, Göblös A, Bacsa S, et al. Expression and functional studies on the noncoding RNA, PRINS[J]. Int J Mol Sci, 2012,14(1):205⁃225. doi: 10.3390/ijms14010205. |
[29] | Sonkoly E, Bata⁃Csorgo Z, Pivarcsi A, et al. Identification and characterization of a novel, psoriasis susceptibility⁃related noncoding RNA gene, PRINS[J]. J Biol Chem, 2005,280(25):24159⁃24167. doi: 10.1074/jbc.M501704200. |
[30] | Szegedi K, Sonkoly E, Nagy N, et al. The anti⁃apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non⁃coding RNA, PRINS[J]. Exp Dermatol, 2010,19(3):269⁃278. doi: 10.1111/j.1600⁃0625.2010.01066.x. |
[31] | Széll M, Danis J, Bata⁃Csörgö Z, et al. PRINS, a primate⁃specific long non⁃coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis[J]. Pflugers Arch, 2016,468(6):935⁃943. doi: 10.1007/s00424⁃016⁃1803⁃z. |
[32] | Danis J, Göblös A, Bata⁃Csörgö Z, et al. PRINS non⁃coding RNA regulates nucleic acid⁃induced innate immune responses of human keratinocytes[J]. Front Immunol, 2017,8:1053. doi: 10.3389/fimmu.2017.01053. |
[33] | Holm SJ, Sánchez F, Carlén LM, et al. HLA⁃Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3[J]. Acta Derm Venereol, 2005,85(1):2⁃8. doi: 10.1080/00015550410023527. |
[34] | Wu GC, Pan HF, Leng RX, et al. Emerging role of long noncoding RNAs in autoimmune diseases[J]. Autoimmun Rev, 2015,14(9):798⁃805. doi: 10.1016/j.autrev.2015.05.004. |
[35] | Li B, Tsoi LC, Swindell WR, et al. Transcriptome analysis of psoriasis in a large case⁃control sample: RNA⁃seq provides insights into disease mechanisms[J]. J Invest Dermatol, 2014,134(7):1828⁃1838. doi: 10.1038/jid.2014.28. |
[36] | Qiao M, Li R, Zhao X, et al. Up⁃regulated lncRNA⁃MSX2P1 promotes the growth of IL⁃22⁃stimulated keratinocytes by inhibiting miR⁃6731⁃5p and activating S100A7[J]. Exp Cell Res, 2018,363(2):243⁃254. doi: 10.1016/j.yexcr.2018.01.014. |
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