高压氧治疗皮肤病的研究进展

摘要/Abstract

摘要：

高压氧治疗是机体在高于一个标准大气压（ATA）的条件下吸入等压的纯氧而达到疗效的一种方法，目前已用于多种皮肤病的辅助治疗。可以肯定的是高压氧可增加皮肤组织内氧含量，加强皮肤的有氧代谢，促进上皮再生和皮损愈合；减轻皮肤末梢神经和感受器的不良刺激；抑制神经元的凋亡；增强调节性T细胞的功能，减轻炎症反应；动员血管干/祖细胞从骨髓迁移至外周血和溃疡组织中。高压氧广泛用于辅助治疗银屑病、特应性皮炎、带状疱疹后遗神经痛、慢性难治性皮肤溃疡、坏疽性脓皮病、真菌感染、面部填充术血管栓塞并发症以及其他皮肤病。

Abstract:

Hao Yangyang, Zhang Liangyu, Chen Yang Department of Dermatology, 98th Hospital of People′s Liberation Army, 98th Clinical College of People′s Liberation Army, Anhui Medical University, Huzhou 313000, Zhejiang, China Corresponding author: Chen Yang, Email: 98cy@163.com 【Abstract】 Hyperbaric oxygen （HBO） therapy is the inhalation of 100% oxygen at a pressure higher than one atmosphere absolute （ATA）, and has been used as an auxiliary therapy for various skin diseases. It has been proved that HBO can increase the oxygen content in skin tissues, accelerate aerobic metabolism of skin, promote epithelial regeneration and wound healing, relieve adverse stimuli on peripheral nerves and sensors in the skin, inhibit apoptosis of neurons, enhance the function of regulatory T cells, alleviate inflammation, and mobilize vascular stem/progenitor cells （SPCs） from the bone marrow to peripheral blood and ulcer tissues. At present, HBO has been widely applied in the auxiliary treatment of psoriasis, atopic dermatitis, postherpetic neuralgia, chronic refractory cutaneous ulcer, pyoderma gangrenosum, fungal infection, vascular embolization after cosmetic facial filling, and some other skin diseases.

中图分类号:

R751

郝阳阳张梁宇陈杨. 高压氧治疗皮肤病的研究进展[J]. 中华皮肤科杂志, 2016, 49(9): 672-675.

Yang-Yang HAO Yang CHEN. Hyperbaric oxygen for the treatment of skin diseases[J]. Chinese Journal of Dermatology, 2016, 49(9): 672-675.

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