中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (7): 445-449.doi: 10.3760/cma.j.issn.0412-4030.2019.07.001

• 专家笔谈 •    下一篇

诱导性多功能干细胞在皮肤科研究与应用的进展

李遇梅    张怡萱    刘莉萍   

  1. 江苏大学附属医院皮肤科  镇江市免疫性皮肤病重点实验室,江苏镇江  212000
  • 收稿日期:2018-09-20 修回日期:2018-12-28 出版日期:2019-07-15 发布日期:2019-07-01
  • 通讯作者: 李遇梅 E-mail:yumeili@ujs.edu.cn
  • 基金资助:
    国家自然科学基金(81573053);镇江市第七批科技计划项目(SS2015024)

Induced pluripotent stem cells: advances in research and application in dermatology

Li Yumei, Zhang Yixuan, Liu Liping   

  1. Department of Dermatology, Affiliated Hospital of Jiangsu University, The Key Laboratory of Immunological Dermatology in Zhenjiang, Zhenjiang 212000, Jiangsu, China
  • Received:2018-09-20 Revised:2018-12-28 Online:2019-07-15 Published:2019-07-01
  • Contact: Li Yumei E-mail:yumeili@ujs.edu.cn
  • Supported by:
    National Natural Science Foundation of China (81573053); The Science and Technology Project in Zhenjiang (SS2015024)

摘要: 【摘要】 诱导性多功能干细胞(iPSC)是通过向体细胞中导入一些特定的多能性转录因子使其重编程为干细胞。相比于传统干细胞,iPSC具有多方面优势,如来源广泛并且可以全能分化,以及更少涉及胚胎干细胞长期争议的取材和伦理问题。在皮肤科,iPSC可以用于制造再生皮肤,构建皮肤疾病模型,为研究皮肤疾病的发病机制提供新的平台,还可以针对特定皮肤疾病进行细胞治疗或基因修正治疗。目前其效果已在动物模型中得到验证,临床试验也正在逐步进行。

关键词: 多能干细胞; 再生医学; 皮肤疾病; 疾病模型, 动物; 基因疗法; 诱导性多功能干细胞

Abstract: 【Abstract】 Induced pluripotent stem cells (iPSCs) are a kind of stem cells induced from somatic cells by reprogramming with some specific pluripotent transcription factors. Compared with traditional stem cells, iPSCs have many advantages, including a wide range of sources, the ability of totipotent differentiation, and less ethical and sourcing issues associated with embryonic stem cells which have been debated for a long time. In dermatology, iPSCs can be used to make regenerative skin, establish models of skin diseases, provide a new platform for studying the pathogenesis of skin diseases, and perform cell treatment or gene modification treatment for specific skin diseases. At present, the application value of iPSCs has been verified among animal models, and clinical trials are also under way.

Key words: Multipotent stem cells, Regenerative medicine, Skin diseases, Disease models, animal, Gene therapy, Induced pluripotent stem cells

中图分类号: 

  • R751.05