皮肌炎皮疹与间质性肺病相关性的研究进展

doi:10.3760/cma.j.issn.0412-4030.2018.10.024

摘要/Abstract

摘要： 皮肌炎是一种常见的自身免疫性结缔组织病，主要累及皮肤和骨骼肌，也可累及内脏器官（如肺、心脏、胃肠道等）。典型皮肌炎同时有皮损和肌肉损害；临床无肌病性皮肌炎有超过6个月的持续特征性皮疹而无肌炎表现［1］。间质性肺病（interstitial lung disease，ILD）是皮肌炎患者主要的死因之一，组织病理表现为弥漫性肺实质、肺泡炎症和间质纤维化，临床表现为活动性呼吸困难［2］。ILD起病初期无特殊症状，难以识别，诊断主要靠高分辨率CT……

关键词: 皮肌炎, 皮疹, 间质性肺病, 自身免疫病, 预后

中图分类号:

R751

鲁静浩周行刘超凡朱鹭冰李明. 皮肌炎皮疹与间质性肺病相关性的研究进展[J]. 中华皮肤科杂志, 2018, 51(10): 779-781.

Lu Jinghao, Zhou Xing, Liu Chaofan, Zhu Lubing, Li Ming. Correlation between dermatomyositis rashes and interstitial lung disease[J]. Chinese Journal of Dermatology, 2018, 51(10): 779-781.

参考文献 34

［1］	Sharma A, Hudson M, Watters K, et al. Rapidly progressive melanoma differentiation⁃associated protein 5⁃positive amyopathic dermatomyositis in an HIV⁃positive patient［J］. JAAD Case Rep, 2017,3（2）:158⁃161. doi: 10.1016/j.jdcr.2017.01.013.<br />
［2］	Alsumrain M, De Giacomi F, Mirza S, et al. Utility of autoimmune serology testing in the assessment of uncharacterized interstitial lung disease: a large retrospective cohort review［J］. Respir Res, 2017,18（1）:161. doi: 10.1186/s12931⁃017⁃0644⁃4.<br />
［3］	Kamiya H, Panlaqui OM, Izumi S, et al. Prognostic factors of idiopathic inflammatory myopathies complicated with interstitial lung disease: protocol for a systematic review and meta⁃analysis［J］. BMJ Open, 2016,6（11）:e012744. doi: 10.1136/bmjopen⁃2016⁃012744.<br />
［4］	Fujisawa T, Hozumi H, Kono M, et al. Predictive factors for long⁃term outcome in polymyositis/dermatomyositis⁃associated inter⁃stitial lung diseases［J］. Respir Investig, 2017,55（2）:130⁃137. doi: 10.1016/j.resinv.2016.09.006.<br />
［5］	Muro Y, Sugiura K, Akiyama M. Cutaneous manifestations in dermatomyositis: key clinical and serological features⁃a comprehensive review［J］. Clin Rev Allergy Immunol, 2016,51（3）:293⁃302. doi: 10.1007/s12016⁃015⁃8496⁃5.<br />
［6］	Sontheimer RD. MDA5 autoantibody⁃another indicator of clinical diversity in dermatomyositis［J］. Ann Transl Med, 2017,5（7）:160. doi: 10.21037/atm.2017.03.94.<br />
［7］	Narang NS, Casciola⁃Rosen L, Li S, et al. Cutaneous ulceration in dermatomyositis: association with anti⁃melanoma differentiation⁃associated gene 5 antibodies and interstitial lung disease［J］. Arthritis Care Res （Hoboken）, 2015,67（5）:667⁃672. doi: 10.1002/ acr.22498.<br />
［8］	Ideura G, Hanaoka M, Koizumi T, et al. Interstitial lung disease associated with amyopathic dermatomyositis: review of 18 cases［J］. Respir Med, 2007,101（7）:1406⁃1411. doi: 10.1016/j.rmed.2007. 01.023.<br />
［9］	Cao H, Xia Q, Pan M, et al. Gottron papules and Gottron sign with ulceration: a distinctive cutaneous feature in a subset of patients with classic dermatomyositis and clinically amyopathic dermato⁃myositis［J］. J Rheumatol, 2016,43（9）:1735⁃1742. doi: 10.3899/jrheum.160024.<br />
［10］	Ishigaki K, Maruyama J, Hagino N, et al. Skin ulcer is a predictive and prognostic factor of acute or subacute interstitial lung disease in dermatomyositis［J］. Rheumatol Int, 2013,33（9）:2381⁃2389. doi: 10.1007/s00296⁃013⁃2735⁃y.<br />
［11］	Xu Y, Yang CS, Li YJ, et al. Predictive factors of rapidly progressive⁃interstitial lung disease in patients with clinically amyopathic dermatomyositis［J］. Clin Rheumatol, 2016,35（1）:113⁃116. doi: 10.1007/s10067⁃015⁃3139⁃z.<br />
［12］	Nagashima T, Iwamoto M, Minota S. Gottron sign with ulceration is not a poor prognostic factor in patients with dermatomyositis and interstitial lung disease［J］. J Rheumatol, 2017,44（7）:1099⁃1100. doi: 10.3899/jrheum.170068.<br />
［13］	Fiorentino D, Chung L, Zwerner J, et al. The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 （CADM⁃140）: a retrospective study［J］. J Am Acad Dermatol, 2011,65（1）:25⁃34. doi: 10.1016/j.jaad.2010.09.016.<br />
［14］	Moghadam⁃Kia S, Oddis CV, Sato S, et al. Antimelanoma differentiation⁃associated gene 5 antibody: expanding the clinical spectrum in north American patients with dermatomyositis［J］. J Rheumatol, 2017,44（3）:319⁃325. doi: 10. 3899/jrheum.160682.<br />
［15］	Sasaki Y, Okuyama R, Tsunoda T, et al. Keratotic palmar papules in a dermatomyositis patient preceding the development of interstitial pneumonia［J］. Dermatology, 2007,215（2）:169⁃170. doi: 10.1159/000104272.<br />
［16］	Koguchi⁃Yoshioka H, Okiyama N, Iwamoto K, et al. Intravenous immunoglobulin contributes to the control of antimelanoma differentiation⁃associated protein 5 antibody⁃associated dermatomyositis with palmar violaceous macules/papules［J］. Br J Dermatol, 2017,177（5）:1442⁃1446. doi: 10.1111/bjd.15499.<br />
［17］	Kameda H, Nagasawa H, Ogawa H, et al. Combination therapy with corticosteroids, cyclosporin A, and intravenous pulse cyclo⁃phosphamide for acute/subacute interstitial pneumonia in patients with dermatomyositis［J］. J Rheumatol, 2005,32（9）:1719⁃1726.<br />
［18］	Ito A, Yamada N, Yoshida Y, et al. Pseudocheckerboard pattern: an interesting histopathological finding in mechanic′s hands［J］. J Cutan Pathol, 2016,43（1）:5⁃11. doi: 10.1111/cup.12583.<br />
［19］	Cen X, Zuo C, Yang M, et al. A clinical analysis of risk factors for interstitial lung disease in patients with idiopathic inflammatory myopathy［J］. Clin Dev Immunol, 2013,2013:648570. doi: 10.1155/ 2013/648570.<br />
［20］	Ang CC, Anyanwu CO, Robinson E, et al. Clinical signs associated with an increased risk of interstitial lung disease: a retrospective study of 101 patients with dermatomyositis［J］. Br J Dermatol, 2017,176（1）:231⁃233. doi: 10.1111/bjd.14801.<br />
［21］	Mori T, Ohashi T, Kato Y, et al. Clinicopathological analysis of mechanic′s hand associated with dermatomyositis［J］. Australas J Dermatol, 2015. doi: 10.1111/ajd.12381.<br />
［22］	Chen YJ, Wu CY, Shen JL. Predicting factors of interstitial lung disease in dermatomyositis and polymyositis［J］. Acta Derm Venereol, 2007,87（1）:33⁃38. doi: 10.2340/00015555⁃0177.<br />
［23］	Morganroth PA, Kreider ME, Okawa J, et al. Interstitial lung disease in classic and skin⁃predominant dermatomyositis: a retro⁃spective study with screening recommendations［J］. Arch Dermatol, 2010,146（7）:729⁃738. doi: 10.1001/archdermatol.2010. 134.<br />
［24］	Kazandjieva J, Tsankov N, Pramatarov K. The red face revisited: connective tissue disorders［J］. Clin Dermatol, 2014,32（1）:153⁃158. doi: 10.1016/j.clindermatol.2013.05.037.<br />
［25］	Wu H, Geng D, Xu J. An approach to the development of interstitial lung disease in dermatomyositis: a study of 230 cases in China［J］. J Int Med Res, 2013,41（2）:493⁃501. doi: 10.1177/0300060513476435.<br />
［26］	Zhang L, Wu G, Gao D, et al. Factors associated with interstitial lung disease in patients with polymyositis and dermatomyositis: a systematic review and meta⁃analysis［J］. PLoS One, 2016,11（5）:e0155381. doi: 10.1371/journal.pone.0155381.<br />
［27］	Ji SY, Zeng FQ, Guo Q, et al. Predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis or dermatomyositis: a retrospective study［J］. Chin Med J （Engl）, 2010,123（5）:517⁃522.<br />
［28］	Sun Y, Liu Y, Yan B, et al. Interstitial lung disease in clinically amyopathic dermatomyositis （CADM） patients: a retrospective study of 41 Chinese Han patients［J］. Rheumatol Int, 2013,33（5）:1295⁃1302. doi: 10.1007/s00296⁃012⁃2545⁃7.<br />
［29］	Labrador⁃Horrillo M, Martinez MA, Selva⁃O′Callaghan A, et al. Anti⁃MDA5 antibodies in a large Mediterranean population of adults with dermatomyositis［J］. J Immunol Res, 2014,2014:290797. doi: 10.1155/2014/290797.<br />
［30］	周行, 鲁静浩, 胡东艳, 等. 以脂膜炎为皮肤表现的皮肌炎九例研究［J］. 中华皮肤科杂志, 2017,50（6）:404⁃407. doi: 10.3760/cma.j.issn.0412⁃4030.2017.06.004.<br />
［31］	阮晨曦, 潘萌, 郑捷. 皮肌炎伴发肺间质病变的相关因素分析［J］. 实用皮肤病学杂志, 2008,1（4）:200⁃203. doi: 10.3969/j.issn.1674⁃1293.2008.04.004.<br />
［32］	魏群, 胡兰廷, 王珍, 等. 98例皮肌炎伴肺间质病变相关因素分析［J］. 中国麻风皮肤病杂志, 2017,33（4）:233⁃236.<br />
［33］	Auriemma M, Capo A, Meogrossi G, et al. Cutaneous signs of classical dermatomyositis［J］. G Ital Dermatol Venereol, 2014,149（5）:505⁃517.<br />
［34］	王培珍, 管剑龙, 韩星海. 多发性肌炎/皮肌炎合并间质性肺疾病的相关因素及预后不良因素分析［J］. 中华结核和呼吸杂志, 2008,31（6）:417⁃420. doi: 10.3321/j.issn:1001⁃0939.2008.06. 005.<br />

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皮肌炎皮疹与间质性肺病相关性的研究进展

Correlation between dermatomyositis rashes and interstitial lung disease

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