中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (10): 739-741.

• 研究报道 • 上一篇    下一篇

氨基酮戊酸光动力疗法治疗尖锐湿疣对病灶乳头瘤病毒复制的影响

王辉1,赵学良2   

  1. 1. 潍坊市人民医院 广文街151号
    2. 山东潍坊市人民医院
  • 收稿日期:2014-01-15 修回日期:2014-04-30 发布日期:2014-10-01
  • 通讯作者: 赵学良 E-mail:zhxl5801@163.com
  • 基金资助:
    山东省潍坊市科技发展计划

Inhibitory effect of 5-aminolevulinic acid photodynamic therapy on human papillomavirus replication in condyloma acuminatum lesions

hui wang1,   

  • Received:2014-01-15 Revised:2014-04-30 Published:2014-10-01

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摘要： 【摘要】 目的 检测氨基酮戊酸光动力方法（ALA-PDT）治疗前后，尖锐湿疣患者病灶局部人乳头瘤病毒（HPV）6/11型DNA载量的变化。 方法 选择电离子去除疣体后HPV6/11阳性患者分为两组，光动力组32例采用ALA-PDT治疗，对照组29例不治疗。3个月后用荧光定量PCR检测病灶局部HPV6/11型DNA载量。结果 3个月后光动力组29例中有26例HPV DNA阴转（89.7%），对照组19例中有13例HPV DNA阴转（68.4%）；光动力组HPV DNA载量为（1.70 × 105 ± 7.86 × 105）拷贝/ml，对照组HPVDNA载量为（1.27 × 106 ± 2.21 × 106）拷贝/ml，两组比较，差异有统计学意义（P < 0.05）。 结论 ALA-PDT能降低尖锐湿疣患者病灶局部HPV病毒载量。

关键词: 尖锐湿疣, 光化学疗法, 人乳头状瘤病毒

Abstract: Wang Hui, Zhao Xueliang. Department of Dermatology, Weifang People′s Hospital, Weifang 261041, Shandong, China Corresponding author: Zhao Xueliang, Email: zhxl5801@163.com 【Abstract】 Objective To detect the changes in DNA loads of human papillomavirus （HPV） type 6/11 in lesions of patients with condyloma accuminatum （CA） before and after 5-aminolevulinic acid photodynamic therapy （ALA-PDT）. Methods After removal of warts by electrocautery, HPV6/11-positive patients with CA were divided into two groups: treatment group （32 cases） receiving two sessions of ALA-PDT with intervals of 7 － 10 days, and control group （29 cases） remaining untreated. Exfoliated cells were collected from the lesional sites of these patients before and 3 months after the first session of ALA-PDT, and fluorescence-based quantitative PCR was conducted to estimate the DNA loads of HPV 6/11 in these cells. Results Three months after the first session of ALA-PDT, 89.7% （26/29） of the patients in the treatment group and 68.4% （13/19） in the control group became HPV DNA negative, with significant differences between the treatment group and control group in the DNA loads of HPV （（1.70 ± 7.86） × 105 vs. （1.27 ± 2.21） × 106 copies/ml, P < 0.05）. Conclusion ALA-PDT can reduce HPV DNA loads in lesions of CA in patients.

Key words: Condylomata acuminata, Photochemotherapy, Human papillomavirus

中图分类号: 

  • R752.5+3

引用本文

王辉 赵学良. 氨基酮戊酸光动力疗法治疗尖锐湿疣对病灶乳头瘤病毒复制的影响[J]. 中华皮肤科杂志, 2014,47(10):739-741. doi:

hui wang. Inhibitory effect of 5-aminolevulinic acid photodynamic therapy on human papillomavirus replication in condyloma acuminatum lesions[J]. Chinese Journal of Dermatology, 2014, 47(10): 739-741.doi: