中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (6): 419-421.

• 论著 • 上一篇    下一篇

116例健康儿童部分皮肤屏障参数检测

李丽1,徐子刚2,马琳1   

  1. 1. 首都医科大学附属北京儿童医院
    2. 北京首都医科大学附属北京儿童医院皮肤科
  • 收稿日期:2012-08-06 修回日期:2012-10-24 出版日期:2013-06-15 发布日期:2013-06-01
  • 通讯作者: 马琳 E-mail:bch_maleen@aliyun.com
  • 基金资助:
    2009年中国医师协会皮肤科医师分会-宝洁基金项目

Evaluation of skin barrier-related parameters in 116 healthy children

Li Li1,   

  • Received:2012-08-06 Revised:2012-10-24 Online:2013-06-15 Published:2013-06-01

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摘要： 【摘要】 目的 了解北京市健康儿童不同部位皮肤理化参数的数值及差别。方法 将北京116名健康儿童分为4组。采用皮肤水分流失测试仪TM300、皮肤水分测试仪CM825及皮肤酸碱度测试仪PH905检测前额、颊前、前臂3个部位的经表皮失水（TEWL）、水分和pH值，皮肤黑素和血红蛋白测试探头MX18测量面部的黑素值。结果 ①不同年龄及不同部位的TEWL值，差异无统计学意义（P > 0.05）；②角质层含水量值（额部、面颊部和前臂）： < 1岁组分别为51.53 ± 15.70、39.88 ± 10.48、50.33 ± 17.54；1 ~ 3岁组分别为49.95 ± 17.88、32.51 ± 12.09、36.10 ± 7.43；4 ~ 6岁组分别为51.37 ± 10.60、31.65 ± 9.01、34.41 ± 8.21；7 ~ 12岁组分别为49.74 ± 10.64、39.99 ± 50.43、29.35 ± 8.10；不同年龄的角质层含水量，差异无统计学意义（P > 0.05）；在不同部位，差异有统计学意义（P < 0.05），颊部和前臂角质层含水量明显低于额部；③pH值（额部、面颊部和前臂）： < 1岁组分别为5.27 ± 0.60、6.12 ± 0.51、5.48 ± 0.45；1 ~ 3岁组分别为4.68 ± 0.58、6.80± 0.55、5.07 ± 0.58；4 ~ 6岁组分别为4.58 ± 0.37、5.70 ± 0.48、5.09 ± 0.49；7 ~ 12岁组分别为4.87 ± 0.51、5.72 ± 0.49、5.09 ± 0.51；不同年龄的pH值，差异无统计学意义（P > 0.05），在不同部位，差异有统计学意义（P < 0.05），颊部pH值明显高于前臂和额部；④不同年龄的面部皮肤黑素值，差异无统计学意义（P > 0.05）。结论 健康儿童皮肤理化参数在不同部位存在一定差异。 【关键词】 儿童； 北京； 皮肤； 屏障

关键词: 皮肤, 儿童, 屏障, 北京

Abstract: LI Li, XU Zi-gang, MA Lin. Department of Dermatology, Beijing Children′s Hospital Affiliated to Capital Medical University, Beijing 100045, China Corresponding author: MA Lin: bch_maleen@yahoo.cn 【Abstract】 Objective To assess and compare physical and chemical properties of skin among different body areas of healthy children at different ages from Beijing. Methods A total of 116 healthy children were recruited from Beijing, China, and classified into four age groups. Tewameter TM300 was used to measure transepidermal water loss （TEWL） value, Corneometer CM825 to estimate stratum corneum hydration, and skin-pH-Meter PH905 to determine skin surface pH, in the forehead, cheek and forearm. The Mexameter MX 18 probe to determine melanin index of the face. Analysis of variance was carried out to assess differences in these parameters among different measurement sites and age groups. Results TEWL value did not differ among different age groups or measurement sites（both P > 0.05）. The stratum corneum hydration value of forehead, cheek and forearm was 51.53 ± 15.70, 39.88 ± 10.48 and 50.33 ± 17.54 respectively in the age group < 1 year, 49.95 ± 17.88, 32.51 ± 12.09 and 36.10 ± 7.43 respectively in the age group 1－3 years, 51.37 ± 10.60, 31.65 ± 9.01 and 34.41 ± 8.21 respectively in the age group 4 － 6 years, 49.74 ± 10.64, 39.99 ± 50.43 and 29.35 ± 8.10 respectively in the age group 7 － 12 years, with significant differences among different measurement sites （P < 0.05） but not between different age groups （P > 0.05）. The cheek and forearm showed lower stratum corneum hydration value than the forehead. No statistical difference was observed in pH value at the same measurement sites between the age group < 1 year （forehead 5.27 ± 0.60, cheek 6.12 ± 0.51 and forearm 5.48 ± 0.45）, 1 － 3 years （forehead 4.68 ± 0.58, cheek 6.80 ± 0.55 and forearm 5.07 ± 0.58）, 4 － 6 years （forehead 4.58 ± 0.37, cheek 5.70 ± 0.48 and forearm 5.09 ± 0.49）, and 7 － 12 years （forehead 4.87 ± 0.51, cheek 5.72 ± 0.49 and forearm 5.09 ± 0.51）, but the cheek had significantly higher pH value than the forearm and forehead （both P < 0.05） . Melanin value on the face did not differ between different age groups（P > 0.05）. Conclusion Physical and chemical properties of skin vary with body sites in healthy children. 【Key words】 Child; Beijing; Skin; Barrier

Key words: skin, Beijing

中图分类号: 

  • R 751