中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (11): 629-631.

• 论著 • 上一篇    下一篇

亚急性湿疹和银屑病患者皮损中半胱氨酰白三烯受体的表达

钟华, 郝飞, 钟白玉, 唐书谦   

  1. 第三军医大学西南医院皮肤科 重庆 400083
  • 收稿日期:2005-12-12 出版日期:2006-11-15 发布日期:2006-11-15
  • 通讯作者: 郝飞, email:haofei@mail.immu.com.cn E-mail:email;haofei@mail.immu.com.cn

Expression of cysteinyl leukotriene receptors in the skin lesions of patients with subacute eczema and psoriasis

ZHONG Hua, HAO Fei, ZHONG Bai-yu, TANG Shu-qian   

  1. Department of Dermatology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
  • Received:2005-12-12 Online:2006-11-15 Published:2006-11-15

PDF

104

赞

摘要： 目的探讨湿疹和银屑病患者皮损中半胱氨酰白三烯受体CysLTR1和CysLTR2的临床意义。方法免疫组化SP法分别检测10例亚急性湿疹和20例寻常性银屑病患者皮损中CysLTR1和CysLTR2的表达,并以外科手术中相应部位皮肤组织作为对照。结果银屑病与湿疹患者皮损中CysLTR1和CysLTR2的表达显著高于正常对照,其阳性细胞主要位于表皮、皮脂腺、毛囊、汗腺、平滑肌及血管壁等;3组中CysLTR1和CysLTR2两型受体间的分布及表达强弱差异无统计学意义。结论人皮肤组织中同时存在CysLTR1和CysLTR2的表达,银屑病与湿疹患者皮损中CysLTR1和CysLTR2的表达增强。

关键词: 湿疹, 银屑病, 受体,白三烯

Abstract: Objectives To investigate the expression of cysteinyl leukotriene receptors 1 (CysLTR1) and 2 (CysLTR2) in the skin lesions of patients with subacute eczema and psoriasis.Methods The expression of CysLTR1 and CysLTR2 was assessed by streptavidin-peroxidase technique in the skin lesions of 10 cases of subacute eczema,20 cases of psoriasis vulgaris,and in normal surgical skin tissues at the corresponding sites of 10 healthy controls.Results CysLTR1 and CysLTR2 simultaneously existed in human skin,and were predominantly located in epidermis,sebaceous glands,hair follicles,sweat glands,smooth muscles and blood vessels.The expression of CysLTRl and CysLTR2 was significantly higher in the lesions of eczema and psoriasis than that in control skin (P<0.05).However there was no significant difference in the distribution or the intensity of the expression between the two subtypes of CysLTRs (P>0.05).Conclusions There are two subtypes of cysteinyl leukotriene receptors,CysLTRl and CysLTR2,coexisting in human skin.Both receptors are highly expressed in the lesional skin of patients with eczema and psoriasis in comparison with that in normal controls.

Key words: Eczema, Psoriasis, Receptors, leukotriene