中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (10): 600-601.

• 论著 • 上一篇    下一篇

血热型/血燥型银屑病患者外周血T淋巴细胞亚群变化

徐丽敏1, 元英俊1, 陈丹2, 张影华2, 谢艳秋2, 赵桂华2, 孙晓惠2, 毛舒和2   

  1. 1. 天津大学化工学院, 300193;
    2. 天津市长征医院
  • 收稿日期:2006-02-24 出版日期:2006-10-15 发布日期:2006-10-15

Variety of T lymphocyte subgroups in peripheral blood from patients with psoriasis of blood-heat/blood-dryness type

XU Li-min1, YUAN Ying-jun1, CHEN Dan2, ZHANG Ying-hua2, XIE Yan-qiu2, ZHAO Gui-hua2, SUN Xiao-hui2, MAO Shu-he2   

  1. School of Chemical Engineering and Technology of Tianiin University, Tianiin 300193, China
  • Received:2006-02-24 Online:2006-10-15 Published:2006-10-15

摘要: 目的 探讨血热型/血燥型银屑病患者外周血T淋巴细胞亚群变化规律,并和正常人作比较.方法 选择血热型银屑病患者35例、血燥型银屑病患者30例和正常人36例的外周血单一核细胞,采用流式细胞分析方法检测T淋巴细胞亚群中CD4+和CD8+的比例.结果 在银屑病患者外周血中,血热CD4M+淋巴细胞明显低于血燥型或正常人,CD8+淋巴细胞明显高于血燥型或正常人,CD4+/CD8+比值明显倒置,而血燥型CD4+和CD8+淋巴细胞与正常人相比没有差异.结论 T淋巴细胞变化可能是血热型/血燥型银屑病辨证求因的主要效应细胞之一.

关键词: 银屑病, 血燥, CD4+, CD8+, T淋巴细胞, 血热

Abstract: Objective To investigate the peripheral blood T lymphocyte profile of patients with psoriasis of blood-heat and blood-dryness type,and to compare it with that of normal controls.Methods Peripheral blood T lymphocyte profile in PBMCs was measured by flow cytometer in 35 patients with psoriasis of blood-heat type and 30 patients with psoriasis of blood-dryness type.Results In the peripheral blood of psoriatic patients of blood-heat type,CD4+ T lymphocyte count and the ratio of CD4/CD8 lymphocytes were significantly decreased,while CD8+ T lymphocyte count was significantly increased as compared to that in the psoriatic patients of blood-dryness type and in healthy controls.The T lymphocyte profile in blood-dryness syndrome psoriatic patients was similar to that in health controls.Conclusions T lymphocytes might be the main differentiating cells to identify pattern and seek disease causes of psoriasis of blood-heat and blood-dryness types.

Key words: Psoriasis, Blood-heat, Blood-dryness, CD4+, CD8+, T lymphocytes