中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (10): 637-639.

• 论著 • 上一篇    下一篇

寻常性银屑病皮损中神经生长因子受体P75NTR和TrkA的表达

叶萍1, 何荣国2, 吴志华3   

  1. 1. 深圳市罗湖区人民医院皮肤科 518001;
    2. 广州市第十二人民医院皮肤科;
    3. 广东医学院附属医院皮肤性病研究所
  • 收稿日期:2005-01-10 发布日期:2005-10-15

Expression of Nerve Growth Factor Receptors:P75 Neurotrophin Receptor and Tyrosine Kinase A in Lesions of Psoriasis Vulgaris

YE Ping1, HE Rong-guo2, WU Zhi-hua3   

  1. Department of Dermatology, The People's Hospital of Luohu District, Shenzhen 518001, China
  • Received:2005-01-10 Published:2005-10-15

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摘要： 目的 探讨神经生长因子受体P75NTR和TrkA在寻常性银屑病发病机制中的作用。方法 应用原位杂交和免疫组化技术对38例寻常性银屑病患者(进行期21例,静止期17例)皮损区、非皮损区及10例正常人皮肤组织中P75NTR和TrkA受体mRNA及蛋白表达水平进行检测。结果 与正常人比较,寻常性银屑病皮损及非皮损区P75NTR和TrkA受体mRNA及蛋白表达水平明显上调,且皮损中的表达明显高于非皮损区(P<0.01);进行期患者皮损与非皮损区P75NTR和TrkA受体mRNA及蛋白表达水平分别高于静止期(P<0.01)。结论 神经生长因子受体P75NTR和TrkA mRNA及蛋白水平在进行期、静止期寻常性银屑病皮损及非皮损区的不同表达,提示神经生长因子可能参与了银屑病的发病。

关键词: 银屑病, 受体, 神经生长因子

Abstract: Objective To investigate the expression of nerve growth factor receptors, P75 neurotrophin receptor (P75NTR) and tyrosine kinase A (TrkA), and to explore their role in the pathogenesis of psoriasis vulgaris. Methods In situ hydridization and immunohistochemical technique were used respectively to detect the expression of P75NTH and TrkA mRNA and proteins in lesional and non-lesional skins of 38 patients with psoriasis vulgaris (21 cases in progressive stage, 17 cases in static stage), and in normal skins of 10 healthy controls. Results In the case of expression of P75NTR and TrkA mRNA and proteins, patients had significantly higher level than the normal control (P<0.01); patients in progressive stage had significantly higher level than those in static stage (P<0.01); the level in lesional skins was higher than that in non-lesional skins (P<0.01). Conclusions Significant difference is found in the expression of P75NTR and TrkA mRNA and proteins between lesional and non-lesional skins or between patients in progressive stage and those in static stage of psoriasis vulgaris, indicating that nerve growth factor may participate in the pathogenesis of psoriasis vulgaris.

Key words: Psoriasis, Receptor, nerve growth factor