间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展

doi:10.35541/cjd.20190012

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (2): 151-154.doi: 10.35541/cjd.20190012

间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展

韩齐心¹ 牛旭平² 刘佳² 齐瑞群¹ 吴严¹

¹中国医科大学附属第一医院皮肤科，沈阳 110001；²太原市中心医院皮肤科 030009

收稿日期:2018-11-05 修回日期:2019-05-22 发布日期:2020-02-01
通讯作者: 吴严 E-mail:jlwuyan@126.com

Role of mesenchymal stem cells and their exosomes in Th17/Treg-related pathogenesis of psoriasis

Han Qixin¹, Niu Xuping², Liu Jia², Qi Ruiqun¹, Wu Yan¹

¹Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; ²Department of Dermatology, Taiyuan Central Hospital, Taiyuan 030009, China

Received:2018-11-05 Revised:2019-05-22 Published:2020-02-01
Contact: Wu Yan E-mail:jlwuyan@126.com

摘要/Abstract

摘要： 【摘要】 Th17/Treg细胞失衡是银屑病发病机制中被普遍认可的免疫发病机制之一。间充质干细胞（MSC）可抑制Th17细胞的增殖分化，诱导Treg细胞增殖。MSC分泌的外泌体是 MSC进行细胞间信息交流与物质转运的重要载体。研究发现，MSC源性外泌体有与MSC类似的免疫调节作用，可抑制Th17细胞增殖，诱导Treg细胞分化。近年来许多研究表明，银屑病患者骨髓及皮损处皮肤MSC的异常与银屑病的发生有关，但其机制尚不清楚。本文阐述正常MSC及其外泌体对维持Th17/Treg平衡的作用，为研究银屑病患者骨髓及皮损处皮肤MSC异常是如何参与到银屑病的发病提供思路。

关键词: 银屑病；间质干细胞；外泌体； Th17细胞； T淋巴细胞, 调节性

Abstract: 【Abstract】 T helper 17 （Th17） cell /regulatory T （Treg）cell imbalance has been widely considered as one of immunopathogeneses of psoriasis. Mesenchymal stem cells （MSC） can inhibit the proliferation and differentiation of Th17 cells, but induce the proliferation of Treg cells. Exosomes secreted by MSC are a kind of important carrier for intercellular communication and material transportation. Studies have found that exosomes from MSC and MSC have similar immunoregulatory function, which can inhibit the proliferation of Th17 cells and induce the differentiation of Treg cells. In recent years, many studies have shown that abnormalities of MSC in bone marrow and skin lesions of psoriasis patients are related to the occurrence of psoriasis, but the mechanism is still unclear. This review elaborates the role of normal MSC and their exosomes in the maintenance of Th17/Treg balance, which provides ideas for studying how abnormalities of MSC in bone marrow and skin lesions of psoriasis patients participate in the occurrence of psoriasis.

Key words: Psoriasis, Mesenchymal stem cells, Exosomes, Th17 cells, T-lymphocytes, regulatory

韩齐心牛旭平刘佳齐瑞群吴严. 间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展[J]. 中华皮肤科杂志, 2020,53(2):151-154. doi:10.35541/cjd.20190012

Han Qixin, Niu Xuping, Liu Jia, Qi Ruiqun, Wu Yan. Role of mesenchymal stem cells and their exosomes in Th17/Treg-related pathogenesis of psoriasis[J]. Chinese Journal of Dermatology, 2020, 53(2): 151-154.doi:10.35541/cjd.20190012

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间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展

Role of mesenchymal stem cells and their exosomes in Th17/Treg-related pathogenesis of psoriasis

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