中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (2): 97-98.

• 论著 • 上一篇    下一篇

银屑病患者皮损中磷脂酰肌醇3激酶过表达

张晓艳1, 马圣清2, 柳惠图3   

  1. 1. 北京中日友好医院 100029;
    2. 北京大学第一医院 100029;
    3. 北京师范大学生物系 100029
  • 收稿日期:2001-03-03 出版日期:2002-04-15 发布日期:2002-04-15
  • 基金资助:
    国家自然科学基金资助课题(9388002)

Up-regulation of Expression of Phosphatidylinositol 3-kinase in Psoriatic Lesions

ZHANG Xiaoyan1, MA Shengqing2, LIU Huitu3   

  1. Department of Dermatology, First Hospital of Medical College of Beijing University, Beijing 100029, China
  • Received:2001-03-03 Online:2002-04-15 Published:2002-04-15

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摘要： 目的 探讨磷脂酰肌醇3激酶(PI3激酶)与银屑病发病的相关性。方法 应用点杂交、原位杂交和免疫组化的方法,分析了12例寻常型银屑病患者皮损区和5例正常人表皮中PI3激酶表达分布特点。结果 银屑病皮损中PI3激酶mRNA和蛋白的表达较正常人皮肤明显增强,银屑病患者与正常人皮肤中PI3激酶基因与蛋白的表达一致。结论 银屑病皮损中PI3激酶过表达可能与银屑病角质形成细胞的过度增殖相关。

关键词: 银屑病, 1-磷脂酰肌醇3-激酶

Abstract: Objective To investigate the correlation between phosphatidylinositol 3-kinase (PI3-kinase) and the pathogenesis of psoriasis. Methods By dot hybridization, in situ hybridization and immunohistochemistry, expression of PI3 kinase was observed in twelve psoriatic and five normal epidermis. Results In psoriatic epidermis, expression of PI3-kinase gene and protein was elevated obviously compared with that of normal skin. Conclusion PI3 kinase may be closely associated with hyperproliferation of psoriatic keratinocytes.

Key words: Psoriasis, 1-Phosphatidylinositol 3-kinase