中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (2): 94-96.

• 论著 • 上一篇    下一篇

角质形成细胞生长因子及神经细胞生长因子在银屑病患者皮损中的表达

颜文飞, 郑敏, 孙国均   

  1. 浙江大学医学院附属第二医院皮肤科 杭州 310006
  • 收稿日期:2001-03-16 出版日期:2002-04-15 发布日期:2002-04-15
  • 基金资助:
    浙江省自然科学基金(399126)

Expression of Keratinocyte Growth Factor and Nerve Growth Factor in Psoriasis and Its Clinical Significance

YAN Wenfei, ZHENG Min, SUN Guojun   

  1. Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2001-03-16 Online:2002-04-15 Published:2002-04-15

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摘要： 目的 探讨角质形成细胞生长因子(KGF)及神经细胞生长因子(NGF)与银屑病的关系及银屑病皮损中间质细胞与角质形成细胞的相互作用。方法 应用免疫组化技术分别检测33例银屑病患者皮损、8例非皮损和13例正常人皮肤中KGF、KGF受体、NGF、NGF受体的表达。结果 KGF、KGF受体在银屑病患者基底层和棘细胞下层有极强的表达,与非皮损组及正常对照组间差异有显着性(P<0.05),而非皮损组与正常对照组间差异无显着性(P>0.05).KGF、KGF受体在真皮层未见表达。NGF、NGF受体则主要表达在颗粒层和棘细胞上层,皮损组与非皮损组之间及非皮损组与正常组之间均差异有显着性(P<0.05)。结论 银屑病患者皮损中KGF及NGF可能介导了角质形成细胞的增殖与分化不全;银屑病皮损中存在着间质细胞和角质形成细胞相互作用的紊乱。

关键词: 银屑病, 表皮生长因子-尿抑胃素, 神经生长因子, 角质形成细胞生长因子

Abstract: Objective To investigate the relationship between keratinocyte growth factor (KGF), nerve growth factor(NGF)and psoriasis;and to study the interaction between keratinocytes and interstitial cells in psoriasis. Methods The expression of KGF, KGF receptor (KGFR), NGF, NGF receptor (NGFR), epidermal growth factor receptor (EGFR) and proliferating cell neuclear antigen (PCNA) was studied with immunohistochemical technique (SP) in lesional skin, non-lesional skin and normal controls. Results Significant overexpression of KGF and KGFR was present in psoriatic basal cell layers and suprabasal cell layers compared to that in non-lesional and normal controls (P<0.05), but was not significant between the non-lesional skin and the controls (P >0.05). Expression of KGF and KGFR was absent in dermis. Expression of NGF and NGFR was observed mainly in granular cell layers and upper spinous layers, and was significantly different between normal controls and non-lesional, between non-lesional and lesional skin (P<0.05). Conclusions KGF and NGF may mediate hyperplasia and incomplete differentiation of keratinocytes in psoriasis. The disorder of interaction between keratinocytes and interstitial cells may exist in psoriasis.

Key words: Psoriasis, Epidermal growth factor urogastrone, Nerve growth factors, Keratinocyte growth factor