中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (2): 92-93.

• 论著 • 上一篇    下一篇

银屑病与扁平苔藓中FasL和穿孔素的检测

徐娟, 郑茂荣, 方跃明, 牟贤龙, 孙君红   

  1. 上海第二军医大学附属长海医院皮肤科 200433
  • 收稿日期:1998-06-13 修回日期:1998-11-18 出版日期:1999-04-15 发布日期:1999-04-15

Detection of Fas-L and Perforin in Psoriasis and Lichen Planus

XU Juan, ZHEN Maorong, FANG Yueming   

  1. Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai 200433
  • Received:1998-06-13 Revised:1998-11-18 Online:1999-04-15 Published:1999-04-15

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摘要： 目的 通过对银屑病与扁平苔藓中FasL和穿孔素的检测,研究这两种疾病中细胞毒性T淋巴细胞的作用方式.方法 免疫组化ABC法.结果 在银屑病组织中FasL和穿孔素均为阳性表达;在扁平苔藓组织中FasL为阴性表达,穿孔素为阳性表达.结论 在银屑病中,细胞毒性T淋巴细胞可能通过FasL和穿孔素两条途径起作用;在扁平苔藓中,细胞毒性T淋巴细胞的作用方式可能仅为穿孔素途径.

关键词: 银屑病, 扁平苔藓, FasL, 穿孔素

Abstract: Objective To study the mode of action of cytotoxic T lymphocytes in psoriasis and lichen planus by detecting Fas-L and perforin in the two diseases. Mehtods Immunohistochemical staining ABC method was used. Results Both Fas-L and perforin were positive expressed in psoriasis. Fas-L was not expressed and perforin was expressed in lichen planus. Conculsion Cytotoxic T lymphocytes might played a role through both Fas-L and perforin pathways in psoriasis. However, cytotoxic T lymphocytes might function through perforin pathway only.

Key words: Psoriasis, Lichen planus, Fas ligand, Perforin