中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (2): 80-81.

• 论著 • 上一篇    下一篇

凉血活血汤治疗进行期银屑病的临床及实验研究

娄卫海, 张志礼, 邓丙戌, 赵云妹   

  1. 北京中医医院皮肤科 100010
  • 收稿日期:1998-06-26 修回日期:1998-11-30 出版日期:1999-04-15 发布日期:1999-04-15

Treatment of Acute Psoriasis with Liang Xue Huo Xue Decoction: A Clinical and Experimental Study

LOU Weihai, ZHANG Zhili, DENG Bingxu   

  1. Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010
  • Received:1998-06-26 Revised:1998-11-30 Online:1999-04-15 Published:1999-04-15

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摘要： 目的 观察中药凉血活血汤治疗进行期银屑病的临床疗效,并探讨其可能的治疗机理.方法 运用银屑病皮损程度评分观察和评价了35例银屑病患者的临床疗效,并检测了治疗前后血浆血栓素B2、6-酮-前列腺素F1α和血清白介素8的水平.结果 患者病情改善,血浆血栓素B2、6-酮-前列腺素F1α和血清白介素8的水平较治疗前降低.白介素8水平尚与银屑病皮损程度评分相关.结论 凉血活血汤是治疗进行期银屑病的一个有效方剂,它的治疗作用可能是通过调节血液中的生物活性物质来实现的.

关键词: 银屑病, 复方(中药), 中药疗法血栓烷B2, 6-酮前列腺素F1α, 白细胞介素-8

Abstract: Objective To observe the clinical efficacy of Liang Xue Huo Xue decoction in the treatment of acute psoriasis vulgaris and to investigate the possible mechanisms. Methods Thirty five patients with psoriasis vulgaris had received the decoction for 8 weeks. Psoriasis area and severity index (PASI) was used to monitor the disease activity. The levels of plasma Thromboxane B2(TXB2)、6-ketoprostaglandin F1 alpha (6-K-PGF1α) and serum IL-8 were measured before and after treatment. Results The mean PASI values fell and the levels of plasma TXB2、6-K-PGF1α and serum IL-8 decreased at the end of treatment. Moreover, the serum level of IL-8 correlated with PASI. Conclusion Liang Xue Huo Xue decoction is effective in the treatment of acute psoriasis. The possible mechanisms of its action might be to adjust the levels of plasma TXB2、6-K-PGF1αand serum IL-8.

Key words: Psoriasis, Composite(CTD), Pharmacotherapy,CTD, Thromboxane B2, 6-Ketoprostaglandin F1 alpha, Interleukin-8