中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (2): 74-76.

• 论著 • 上一篇    下一篇

蛋白激酶Cζ在银屑病发病中的意义

张晓艳1, 马圣清1, 柳惠图2   

  1. 1. 北京医科大学第一医院皮肤科 100034;
    2. 北京师范大学生物系
  • 收稿日期:1998-04-15 修回日期:1998-08-15 出版日期:1999-04-15 发布日期:1999-04-15
  • 基金资助:
    国家自然科学基金(39430080);高等学校博士学科点专项基金

Significance of Protein Kinase Cζin Pathogenesis of Psoriasis

ZHANG Xiaoyan1, MA Shengqing1, LIU Huitu2   

  1. Department of Dermatology, The First Hospital, Beijing Medical University, Beijing 100034
  • Received:1998-04-15 Revised:1998-08-15 Online:1999-04-15 Published:1999-04-15

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摘要： 目的 探讨蛋白激酶Cζ在银屑病发病中的作用.方法 通过原位杂交和免疫组化的方法,研究了12例寻常型银屑病患者皮损区、非皮损区和5例正常人表皮中蛋白激酶Cζ的mRNA和蛋白的表达及分布特点.结果 银屑病皮损区表皮中PKCζ的mRNA和蛋白表达均较非皮损区和正常表皮中的表达明显增强,正常人表皮中PKCζ的mRNA表达分布于表皮上层,而银屑病皮损区PKCζ的mRNA表达几乎分布于表皮全层.结论 PKCζ在银屑病表皮中的过表达提示,PKCζ可能与银屑病表皮细胞的过度增殖相关.

关键词: 银屑病, 蛋白激酶-C

Abstract: Objective To investigate the effects of protein kinase Cζ(PKCζ) on the pathogenesis of psoriasis. Methods The expression and distribution of PKCζwere studied by in situ hybridization and immunohistochemistry in 12 cases of psoriasis. Results The expressions of both PKCζmRNA and the protein were significantly higher in psoriatic epidermis than those in normal epidermis and uninvolved epidermis of psoriatic cases. The expression of PKCζmRNA was located in the upper layers of normal epidermis but the expression was almost in the whole layer in psoriatic epidermis. Conclusion The overexpression of PKCζin psoriatic epidermis suggests that PKCζ might be related to the hyperproliferation of psoriatic keratinocytes.

Key words: Psoriasis, Protein kinase C