中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 360-362.

• 论著 • 上一篇    下一篇

钙泊三醇外用治疗可减少银屑病皮损中ICAM-3阳性浸润细胞的表达

蔡绥勍, 郑敏, 孙国均   

  1. 浙江医科大学附属第二医院皮肤科, 杭州 310009
  • 收稿日期:1997-09-22 修回日期:1998-01-04 出版日期:1998-12-15 发布日期:1998-12-15

Topical Treatment of Calcipotriol Decreases Expression of ICAM-3 Positive Infiltrating Leukocytes in Psoriatic Skin

Cai Suiqing, Zheng Min, Sun Guojun   

  1. Department of Dermatology, the Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009
  • Received:1997-09-22 Revised:1998-01-04 Online:1998-12-15 Published:1998-12-15

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摘要： 目的 了解钙泊三醇局部外用治疗对银屑病皮损中细胞间粘附分子3(ICAM-3)表达的影响.方法 采用ABC免疫组化法对20例银屑病患者皮损与非皮损部位以及皮损部位治疗前后的ICAM-3、Ki-67和其它免疫分子的表达进行了研究.结果 银屑病皮损部位ICAM-3阳性浸润细胞的表达均明显高于非皮损部位及正常对照组(P均<0.01), 而且ICAM-3的表达和皮损部位Ki-67.CD3等免疫分子的表达呈正相关.经钙泊三醇外用治疗6周后、皮损部位ICAM-3、Ki-67和CD3的表达均明显减少(P均<0.01).结论 外用钙泊三醇治疗银屑病的机制除了有抗角朊细胞增殖的作用外, 对可能参与银屑病发病机制的ICAM-3阳性浸润细胞也有作用.

关键词: 银屑病, 钙泊三醇, 胞间粘附分子

Abstract: Objective To study the effeet of topical caleipotriol treatment on the expression ICAM-3 molecule in infiltrating leukoeyles of skin lesions of patients with psoriasis berore and after lrealmenl.Methods Expression of ICAM-3. Ki-67 and CD3 was studied in the skin biopsies from 20 palients with chronicn plaque type psoriasis before and after topeal ealeipotriol treatment by using an immnohistoehieal leehnique-Adin biotin Complex(ABC)System Results ICAM-3.Ki-67 and CD3 posilive slaining cells in the skin lesions were significanlly higher than those in uninvolved skin as well as those of normal controls.and there was a posilive conelation between the lesional expression of ICAM-3 and Ki-67 molecues, as well as between lesional expression of ICAM-3 and CD3 molecules.After six weeks of topieal applieation with eaeopotriol the expression of ICAM-3. Ki-67 and CD3 in involved skin were significant decreased(P<0.01).Conclusion It is indieated thai the.meehanism of topical tretment wiih caleipotriol in psoriasis involves not only only inbibiting keralinoeyte poliferation.but also effecting ICAM-3 infirating leukoeyvtes in lesional skin.which may be involved in the pathogenesis of psoriasis.

Key words: Psoriasis, Caleipotriol, Intercellular adhesion molecule