中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (2): 97-99.

• 论著 • 上一篇    下一篇

银屑病患者血清中神经免疫蛋白与淋巴细胞转化的研究

杨雪琴1, 邵黎2, 那爱华1, 郭秀兰1, 庞晓文3, 李世荫3, 范少光2   

  1. 1. 空军总医院皮肤科, 北京 100036;
    2. 北京医科大学生理学系;
    3. 北京医科大学第三医院皮肤科
  • 收稿日期:1997-10-05 修回日期:1998-01-04 出版日期:1998-04-15 发布日期:1998-04-15

The Study of Neuro-immune Protein and the Lymphocyte Transformation in Psoriatic Serum

Yang Xueqin1, Shao Li2, Na Aihua1   

  1. Department of Dermatology, Airforce General Hospital, Beijing 100036
  • Received:1997-10-05 Revised:1998-01-04 Online:1998-04-15 Published:1998-04-15

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摘要： 目的 为了解紧张、压抑等心理因素诱发、加重银屑病的物质基础。方法 采用放射免疫法测定了49例银屑病患者和34例正常人血清对正常小鼠淋巴细胞转化的影响;以及用神经免疫蛋白(NIP)单克隆抗体中和银屑病患者血清,然后对正常小鼠淋巴细胞转化的抑制作用的试验。结果 银屑病患者血清对正常小鼠淋巴细胞的转化率为41.55%,正常人血清对正常小鼠淋巴细胞的转化率为68.09%,表明银屑病患者血清中有抑制正常小鼠淋巴细胞转化的物质,进行期患者血清中的抑制作用大于静止期,即皮损面积愈大者其血清对小鼠淋巴细胞转化率的抑制作用愈强(P<0.01,r=0.4939)。结论 银屑病患者血清中存在抑制淋巴细胞转化的物质,通过NIP单克隆抗体中和试验证明此物质与NIP相同或类似,但NIP与银屑病发生和发展的因果关系有待进一步研究。

关键词: 银屑病, 神经免疫蛋白, 淋巴细胞转化

Abstract: Objective To find out the material base of the induction and aggravation of psoriasis by psycological factors such as stress and depression etc. Methods Radioimmunoassay (RIA) was used to determine the effect of sera from 49 psoriatic patients and 34 healthy controls on the suppression of the lymphocyte transformation of normal mouse lymphocytes. Results The lymphocyte transformation rate of mouse lymphocytes treated with the sera of psoriatic patients was 41.55%, and that of controls was 68.09%. The suppressive effect of sera in patients during the progressive stage and with more extensive lesions were stronger than that in the stable stage and with less lesions (P<0.01, r=0.4939). The lymphocyte transformation rate was increased after adding neuro immune protein (NIP) monoclonal antibody to the sera of patients with psoriasis. Conclusion The authors suggest that there is a factor which can suppress lymphocyte transformation existed in psoriatic patients serum, and it is similar to NIP, which can be neutralized by NIP monoclonal antibody, but the relationship between NIP and the pathogenesis of psoriasis remains to be studied.

Key words: Psoriasis, Neuro-immune protein, Lymphocyte transformation