中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (2): 90-93.

• 论著 • 上一篇    下一篇

银屑病患者血清游离脂肪酸组分的研究

方栩, 胡跃, 刘承煌   

  1. 上海医科大学华山医院皮肤科 200040
  • 收稿日期:1997-03-17 修回日期:1997-10-14 出版日期:1998-04-15 发布日期:1998-04-15

Study on the Composition of Serum Free Fatty Acid in Psoriasis Vulgaris

Fang Xu, Hu Yue, Liu Chenghuang   

  1. Department of Dermatology, Hua Shan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1997-03-17 Revised:1997-10-14 Online:1998-04-15 Published:1998-04-15

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摘要： 目的 研究银屑病患者易患心血管病的发病机理。方法 用气相色谱法测定33例寻常型银屑病的血清游离脂肪酸组分。结果 随着病情的加重,多价不饱和脂肪酸(PUFA)增高,单价不饱和脂肪酸及饱和脂肪酸(SFA)减少,PUFA/SFA比值增高。亚油酸的改变尤为突出,其在进行期和泛发性组中极其显著高于正常人组和(或)静止期组,同时伴有油酸的减少。银屑病患者血清游离脂肪酸组分的变化与大部分心血管疾病的变化不完全相同。结论 银屑病严重时肝脂肪代谢加速,亚油酸增多可能与大量粒层缺失有关,其为花生四烯酸的产生提供了充足的来源。皮损所致的血清游离脂肪酸组分大波动,是否为引起心血管病变的环节,有待进一步研究。

关键词: 银屑病, 脂肪酸类, 非酯化, 亚油酸类

Abstract: Objective To investigate the pathogenesis of the susceptibility to cardiovascular diseases in patients with psoriasis. Methods The composition of serum free fatty acid(FFA) were measured by gaschromatography in 33 patients with psoriasis vulgaris and normal individuals. Results ① Along with the increase of severity of psoriasis the levels of poly-unsaturated fatty acid(PUFA) increased, mono-unsaturated fatty acid (MUFA) and saturated fatty acid (SFA) decreased and PUFA/SFA ratio increased. ② The level of linoleic acid (LA) was significantly higher in the patients of progressive stage and with extensive skin lesions than that in the normal group and/or stationary stage, and the level of oleic acid decreased. ③ The changes of the composition of FFA in patients with psoriasis were diffrent from the majority of the reports studied in the patients with cardiovascular disease. Discussion and Conclusion In the severe stage of psoriasis, the metabolism of fat in the liver is accelerated; the increase of LA, which supplies enough precursor for arachidonic acid metabolism, might be related to the loss of granular layer of epidermis. The changes of FFA induced by psoriasis might be a link causing cardiovascular disease but it should be studied further.

Key words: Psoriasis, Fatty acids,nonesterified, Linoleic acids