中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 30-31.

• 论著 • 上一篇    下一篇

血小板衍生生长因子受体在硬皮病皮损的表达

郑学毅1, 马圣清3, 张建中2, 李翠贞1, 蔡小燕1   

  1. 1. 广州市第一人民医院内科, 510180;
    2. 北京医科大学人民医院;
    3. 北京医科大学第一医院
  • 收稿日期:1997-04-21 修回日期:1997-09-04 出版日期:1998-02-15 发布日期:1998-02-15

The Expression of Platelet-derived Growth Factor Receptor in Scleroderma Lesion

Zheng Xueyi1, Ma Shengqing3, Zhang Jianzhong2   

  1. The First Municipal People's Hospital Guangzhou, Guangzhou 510000
  • Received:1997-04-21 Revised:1997-09-04 Online:1998-02-15 Published:1998-02-15

PDF

507

赞

摘要： 目的 探讨血小板衍生生长因子 (PDGF)在硬皮病发病中的作用。方法 选用特异性多克隆抗体以免疫组化方法检测了8例硬皮病患者和9例正常皮肤标本PDGF受体的表达。结果 研究发现PDGF受体α和β亚单位在8例硬皮病患者皮损表达均明显增高,而9例正常皮肤中仅少数标本呈微弱表达,此差异经统计学检验显示有显著性意义 (P<0.05)。结论 PDGF受体α和β亚单位表达的增高可能与硬皮病纤维化的形成相关。

关键词: 硬皮病, 成纤维细胞, 血小板衍生生长因子

Abstract: Objective To investigate the role of platelet-derived growth factor (PDGF) receptor in the development of scleroderma fibrosis.Methods The expression of PDGF receptor was detected in skin biopsy specimens of 8 scleroderma patients and 9 healthy individuals by imm unohistochemical staining using specific polyclonal antibodies. Results PDGF receptor subunits α and β expression was markedly increased in all of the scleroderma lesions,whereas PDGF receptor was weakly expressed in a few normal skin specimens,the difference was significant (P<0.05). Conclusion The increased expression of PDGF receptor subunits may be related to the development of fibrosis of scleroderma.

Key words: Scleroderma, Fibroblasts, Platelet-derived growth factor