中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (5): 281-283,329.

• 论著 • 上一篇    下一篇

银屑病家系与HLA致病单倍型研究

李世泰1, 安家滨2, 徐林敏2   

  1. 1. 中国医学科学院北京协和医院, 100730;
    2. 北京市儿科研究所白细胞室
  • 收稿日期:1993-10-23 修回日期:1944-04-04 出版日期:1994-10-15 发布日期:1994-10-15

Study on HLA Susceptible Haplotype of Psoriasis in 23 Families

LI Shi-Tai1, AN Jia-Bin2, XU Lin Min2   

  1. Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730
  • Received:1993-10-23 Revised:1944-04-04 Online:1994-10-15 Published:1994-10-15

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摘要： 报告23个多发银屑病家系及59例无亲缘关系银屑病患者HLA抗原频率分布。其增高的抗原为HLA-A19,B13、DR7(Pc<0.001),降低的抗原为HLA-C7,DQ1,(Pc<0.001),提示具有(Cw(C7)者对银屑病的发生具有某种防护作用。23个家系中,健康同胞55例,其中20例与患病同胞有一条或两条单倍型相同,经6～8年观察,4例已发病;另35例无相同单倍型者,未发病。提示对银屑病家系检测HLA单倍型有助于对具有致病单倍型的健康同胞的临床监测。

关键词: 银屑病

Abstract: This article reports the results of HLA antigen distribution in 23 families with multiple affected siblings alld 59 unrelated patients with psoriasis vulgaris. The frequency of HLA-A19, B13 and DR7 was significantly higher(Pc<0.001) than that of controls. It seems that the lower frequency of C7 and DQ1 is resistant to the development of psoriasis. Fifty-five health siblings in 23 families were observed for six to eight years. 20 out of 55 siblings had one or two same HLA haplotypes. Among the 20 persons, 4 siblings had psoriasis vulgaris,35 out of 55 siblings had no similar HLA haplotype and have not affected with psoriasis vulgaris up to now. It shows that HLA haplotype determination is helpful for the clinical surveillance of their healthy sibling with susceptible haplotype.

Key words: Psoriasis, Susceptible haplotype, Polygenic inheritance