中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (3): 152-154.

• 论著 • 上一篇    下一篇

银屑病患者姐妹染色单体互换频率和rRNA基因活性的研究

徐春霞1, 王诗淇1, 傅世珍1, 李景月1, 陈勇夫2   

  1. 1. 河南医科大学第一附属医院皮肤科 郑州 455052;
    2. 河南医科大学生物教研室
  • 收稿日期:1991-01-02 修回日期:1991-08-17 出版日期:1992-06-15 发布日期:1992-06-15

Prsiiminxry study on SCE arid activity of rRNA genes in the patients with psoroasis

XU Chun-Xia1, WANG Shi-Qi1   

  1. The First Affiliated Hospital, Henan University, Zhongzhou, 450052
  • Received:1991-01-02 Revised:1991-08-17 Online:1992-06-15 Published:1992-06-15

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摘要： 观察了一组寻常型银屑病患者的自发及丝裂霉素C诱发姐妹染色单体互换频率和银染核仁形成区及银染近端着丝粒染色体联合频率的变化.结果提示:银屑病患者的DNA不稳定性增加,DNA修复能力低下,其有转录活性的rRNA基因数目增多,且转录活性增强.

关键词: 银屑病, 姐妹染色单体交换, 丝裂霉素C, 核糖核酸,信使

Abstract: The frequency alterations of SCE spontaneous and MMGinducing SCE,silver staining nucleolus organizer legion (Ag-NGIt) aad silver sWniag satellite associaLions of acrocentric chromosome (Ag-AA) of lymphocytes were studied in a group of patients with psoxiasrs vulgaris. The results indicated that frequencies of spozttaneous and MMC-inducing SCE,Ag-NOR in group D chromosome and Ag-AA in group D-D and in group D-G chromasome in patients with psoriasis vulgaris were significantly highter than those in normal corltrots. Moreover, the frequencies of SCE sgontarseaus and Ag-AA in group D-D chromosome in patients with family history of psoriasis were markedly higher than those without family history of psoriasis.

Key words: Psotiasis, Sister chromatid exchenge, Mitamycln C, RNA, messenger