中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (3): 155-157.

• 论著 • 上一篇    下一篇

斑秃与脂溢性秃发患者β-内啡肽与自然杀伤细胞活性的检测

郑捷, 高博铎, 钟济华, 俞平, 戴虹, 倪华妹, 陆树良, 张传钧   

  1. 上海第二医科大学附属瑞金医院皮肤科临床免疫室 200025
  • 收稿日期:1991-02-18 修回日期:1991-06-19 出版日期:1992-06-15 发布日期:1992-06-15

Determinatioti of plasma β-endorphin and natural killer activity in patients with alopecia areata and male pattern alopecia

ZHENG Jie, GAO Bu-Duo   

  1. Runjin Hospital, Shanghai No.2 Medical University, 200025
  • Received:1991-02-18 Revised:1991-06-19 Online:1992-06-15 Published:1992-06-15

摘要: 用RIA和LDH释放法对斑秃(含全秃),脂滋性秃发(脂秃)及正常人的血浆β-内啡肽免疫活性物质(irβ-Ep)水平和外周血自然杀伤细胞(NKC)活性同时进行了检测.结果显示斑秃患者的irβ-Ep水平与NKC活性较正常人显著降低,其中尤以全秃患者的降低更为显著,而脂秃的irβ-Ep水平与NKC活性与正常人无显著性差异.irβ-Ep水平与NKC活性在A组间呈正相关.显示斑秃与脂秃在发病机理上有着明显的区别.我们认为斑秃的irβ-Ep水平降低可能与患者的情绪、性格、发病前所受到的社会生活事件影响有密切关联,认为可能由于β-Ep水平的降低引起免疫调节细跑-NKC的活性受损.

关键词: 斑秃, β-内啡肽, 杀伤细胞,天然

Abstract: In order to evaluate the relation between neztroendocrinc and immunoregulating cell in patients with alopecia areata and male pattern alopecia, we determined the fevel of plasma (3-endorphin immunoreactivity(irβ-Ep) by RIA and the activity of natural killer cell (NKC) by enryme-release (LDH)assay in patients with alopecia areaEa(AA),including alopecia totalis(AT) and in patients with male pattern alopecia (MPA). The majority of AA patients to be determined were examined within one manth since their fait loss.Normal subjects (NS) were also determined as the control group.

Key words: Alopacia areata, Beta-endorphin, Killer cells, natural