特应性皮炎相关细胞因子对皮肤屏障的影响

doi:10.3760/cma.j.issn.0412-4030.2019.01.016

中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (1): 46-49.doi: 10.3760/cma.j.issn.0412-4030.2019.01.016

特应性皮炎相关细胞因子对皮肤屏障的影响

张南王莲刘莲张自晖蒋献

四川大学华西医院皮肤科，成都 610041

收稿日期:2018-01-29 修回日期:2018-08-23 发布日期:2019-01-02
通讯作者: 蒋献 E-mail:jennyxianj@163.com

Effect of atopic dermatitis-related cytokines on skin barrier

Zhang Nan, Wang Lian, Liu Lian, Zhang Zihui, Jiang Xian

Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China

Received:2018-01-29 Revised:2018-08-23 Published:2019-01-02
Contact: Jiang Xian E-mail:jennyxianj@163.com

摘要/Abstract

摘要： 【摘要】皮肤是人体最大的器官，是一个重要的屏障。特应性皮炎患者存在皮肤屏障功能异常，同时其细胞因子的组成与健康人不同。在特应性皮炎患者皮肤中发现的许多细胞因子能够影响角质形成细胞的分化和角化过程。本文综述了特应性皮炎相关细胞因子的最新进展及其对皮肤屏障功能的影响，这些结果有利于了解特应性皮炎的发病机制，并可能为特应性皮炎的治疗提供新的方向。

关键词: 皮炎, 特应性；白细胞介素类；细胞因子类；皮肤屏障

Abstract: 【Abstract】 The skin is the largest organ of the human body, and is an important barrier. There is dysfunction of skin barrier in patients with atopic dermatitis （AD）, and the composition of cytokines in patients with AD is different from healthy persons. Many cytokines found in the skin of AD patients can affect the differentiation and cornification of keratinocytes. This review summarizes the latest advances in AD-related cytokines and their effect on skin barrier function. These results are helpful to understand the pathogenesis of AD, and may provide new directions for the treatment of AD.

Key words: Dermatitis, atopic, Interleukins, Cytokines, Skin barrier

张南王莲刘莲张自晖蒋献. 特应性皮炎相关细胞因子对皮肤屏障的影响[J]. 中华皮肤科杂志, 2019,52(1):46-49. doi:10.3760/cma.j.issn.0412-4030.2019.01.016

Zhang Nan, Wang Lian, Liu Lian, Zhang Zihui, Jiang Xian. Effect of atopic dermatitis-related cytokines on skin barrier[J]. Chinese Journal of Dermatology, 2019, 52(1): 46-49.doi:10.3760/cma.j.issn.0412-4030.2019.01.016

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特应性皮炎相关细胞因子对皮肤屏障的影响

Effect of atopic dermatitis-related cytokines on skin barrier

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