自身免疫相关B细胞在自身免疫性疾病中的作用

doi:10.35541/cjd.20230715

中华皮肤科杂志 ›› 2026, e20230715.doi: 10.35541/cjd.20230715

自身免疫相关B细胞在自身免疫性疾病中的作用

沈依听¹ 朱海琴¹ 张慧慧² 潘萌¹

¹上海交通大学医学院上海瑞金医院皮肤科，上海 200025；²上海交通大学医学院基础医学院免疫与微生物学系上海市免疫学研究所，上海 200025

收稿日期:2023-12-05 修回日期:2026-01-17 发布日期:2026-07-16
通讯作者: 潘萌；张慧慧 E-mail:pm10633@rjh.com.cn; huizha@shsmu.edu.cn
基金资助:
国家自然科学基金项目（82430100，82273514，32070885）

Role of autoimmune-associated B cells in autoimmune diseases

Shen Yiting¹, Zhu Haiqin¹, Zhang Huihui², Pan Meng¹

¹Department of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; ²Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China

Received:2023-12-05 Revised:2026-01-17 Published:2026-07-16
Contact: Pan Meng; Zhang Huihui E-mail:pm10633@rjh.com.cn; huizha@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China（82430100，82273514，32070885）

摘要/Abstract

摘要： 【摘要】自身免疫/年龄相关B细胞是一群随年龄增长而积累的B细胞亚群,具有独特表型和功能。除了具有分泌抗体的潜力，其还能通过激活T细胞的功能、分泌细胞因子等参与炎症反应。许多研究证据表明自身免疫相关B细胞在自身免疫性疾病中异常扩增并在其发病过程中发挥重要作用。本文主要介绍自身免疫相关B细胞的特征、起源和功能，及其在系统性红斑狼疮、类风湿关节炎等自身免疫性疾病中的潜在致病机制。

关键词: 自身免疫相关B细胞, 年龄相关B细胞, 自身免疫

Abstract: 【Abstract】 Autoimmune/age?associated B cells are a phenotypically and functionally distinct B cell subset that accumulates with age. In addition to producing antibodies, these cells participate in inflammatory responses by activating T?cell function and secreting cytokines. Accumulating evidence indicates that autoimmune?associated B cells are abnormally expanded in autoimmune diseases and play a critical role in their pathogenesis. This review summarizes the characteristics, origins, and functions of autoimmune?associated B cells, as well as their potential pathogenic mechanisms in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.

Key words: Autoimmune?associated B cells, Age?associated B cells, Autoimmunity

沈依听朱海琴张慧慧潘萌. 自身免疫相关B细胞在自身免疫性疾病中的作用[J]. 中华皮肤科杂志, 2026,e20230715. doi:10.35541/cjd.20230715

Shen Yiting, Zhu Haiqin, Zhang Huihui, Pan Meng. Role of autoimmune-associated B cells in autoimmune diseases[J]. Chinese Journal of Dermatology,2026,e20230715. doi:10.35541/cjd.20230715

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自身免疫相关B细胞在自身免疫性疾病中的作用

Role of autoimmune-associated B cells in autoimmune diseases

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