中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (9): 835-838.doi: 10.35541/cjd.20200324

• 综述 • 上一篇    下一篇

干细胞治疗斑秃的研究进展

丁雨欣    吕中法   

  1. 浙江大学医学院附属第二医院皮肤科，杭州  310009
  • 收稿日期:2020-04-03 修回日期:2020-09-08 发布日期:2022-09-02
  • 通讯作者: 吕中法 E-mail:lzfskin@zju.edu.cn
  • 基金资助:
    国家自然科学基金（81972959）

Stem cell therapy for alopecia areata

Ding Yuxin, Lyu Zhongfa   

  1. Department of Dermatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2020-04-03 Revised:2020-09-08 Published:2022-09-02
  • Contact: Lyu Zhongfa E-mail:lzfskin@zju.edu.cn
  • Supported by:
    National Natural Science Foundation of China（81972959）

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摘要： 【摘要】 目前认为，斑秃是由于毛囊免疫赦免被破坏导致。干细胞具有免疫调节功能，可分泌多种细胞因子，促进毛囊免疫赦免。干细胞治疗，尤其是脐带和脂肪来源的干细胞相关疗法已应用于多种脱发的临床前和临床研究，为难治性斑秃提供了治疗新途径。

关键词: 斑秃, 干细胞, 脂肪来源干细胞, 脐带干细胞, 间充质干细胞

Abstract: 【Abstract】 It is currently considered that alopecia areata is caused by the impairment of immune privilege in hair follicles. Stem cells have immunoregulatory functions, and can secrete a variety of cytokines to promote immune privilege in hair follicles. Stem cell therapy, especially umbilical cord- and adipose-derived stem cell therapy, has been applied to a variety of preclinical and clinical studies on alopecia, providing a new approach to refractory alopecia areata.

Key words: Alopecia areata, Stem cells, Adipose-derived stem cells, Umbilical cord-derived stem cells, Mesenchymal stromal cells