中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (9): 830-834.doi: 10.35541/cjd.20200279
肖春英 王刚
收稿日期:
2020-03-19
修回日期:
2020-10-21
发布日期:
2022-09-02
通讯作者:
王刚
E-mail:xjwgang@fmmu.edu.cn
基金资助:
Xiao Chunying, Wang Gang
Received:
2020-03-19
Revised:
2020-10-21
Published:
2022-09-02
Contact:
Wang Gang
E-mail:xjwgang@fmmu.edu.cn
Supported by:
摘要: 【摘要】 朗格汉斯细胞(LC)是表皮内重要的免疫细胞,具有抗原提呈功能,在炎症状态下经过成熟、活化后,迁移至局部淋巴结并活化初始T细胞,启动免疫应答。近年对LC在银屑病发病中的研究显示,LC具有促进炎症和抑制炎症的双重作用。对LC起源的研究显示,LC有两个亚群,分别具有促炎和抑炎作用,参与不同的免疫应答过程,可能与银屑病免疫异常有关。本文综述LC在银屑病中的研究进展。
肖春英 王刚. 朗格汉斯细胞在银屑病中的作用研究进展[J]. 中华皮肤科杂志, 2022,55(9):830-834. doi:10.35541/cjd.20200279
Xiao Chunying, Wang Gang. Roles of Langerhans cells in psoriasis[J]. Chinese Journal of Dermatology, 2022, 55(9): 830-834.doi:10.35541/cjd.20200279
[1] | West HC, Bennett CL. Redefining the role of Langerhans cells as immune regulators within the skin[J]. Front Immunol, 2017,8:1941. doi: 10.3389/fimmu.2017.01941. |
[2] | Deckers J, Hammad H, Hoste E. Langerhans cells: sensing the environment in health and disease[J]. Front Immunol, 2018,9:93. doi: 10.3389/fimmu.2018.00093. |
[3] | Atmatzidis DH, Lambert WC, Lambert MW. Langerhans cell: exciting developments in health and disease[J]. J Eur Acad Dermatol Venereol, 2017,31(11):1817⁃1824. doi: 10.1111/jdv. 14522. |
[4] | Otsuka M, Egawa G, Kabashima K. Uncovering the mysteries of langerhans cells, inflammatory dendritic epidermal cells, and monocyte⁃derived Langerhans cell⁃like cells in the epidermis[J]. Front Immunol, 2018,9:1768. doi: 10.3389/fimmu.2018.01768. |
[5] | Chorro L, Sarde A, Li M, et al. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation⁃associated expansion of the epidermal LC network[J]. J Exp Med, 2009,206(13):3089⁃3100. doi: 10.1084/jem. 20091586. |
[6] | Hasegawa T, Feng Z, Yan Z, et al. Reduction in human epidermal Langerhans cells with age is associated with decline in CXCL14⁃mediated recruitment of CD14+ monocytes[J]. J Invest Dermatol, 2020,140(7):1327⁃1334. doi: 10.1016/j.jid. 2019.11.017. |
[7] | Kubo A, Nagao K, Yokouchi M, et al. External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers[J]. J Exp Med, 2009,206(13):2937⁃2946. doi: 10.1084/jem.20091527. |
[8] | Ogawa Y, Kinoshita M, Shimada S, et al. Zinc in keratinocytes and Langerhans cells: relevance to the epidermal homeostasis[J]. J Immunol Res, 2018,2018:5404093. doi: 10.1155/2018/5404093. |
[9] | Kaplan DH. Ontogeny and function of murine epidermal Langerhans cells[J]. Nat Immunol, 2017,18(10):1068⁃1075. doi: 10.1038/ni.3815. |
[10] | Ginhoux F, Collin MP, Bogunovic M, et al. Blood⁃derived dermal langerin+ dendritic cells survey the skin in the steady state[J]. J Exp Med, 2007,204(13):3133⁃3146. doi: 10.1084/jem.20071733. |
[11] | Sirvent S, Vallejo AF, Davies J, et al. Genomic programming of IRF4⁃expressing human Langerhans cells[J]. Nat Commun, 2020,11(1):313. doi: 10.1038/s41467⁃019⁃14125⁃x. |
[12] | Hovav AH. Mucosal and skin Langerhans cells ⁃ nurture calls[J]. Trends Immunol, 2018,39(10):788⁃800. doi: 10.1016/j.it. 2018.08.007. |
[13] | Wu X, Briseño CG, Durai V, et al. Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells[J]. J Exp Med, 2016,213(12):2553⁃2565. doi: 10.1084/jem.20160600. |
[14] | Satpathy AT, Brown RA, Gomulia E, et al. Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin[J]. Mod Pathol, 2018,31(9):1479⁃1486. doi: 10.1038/s41379⁃018⁃0052⁃4. |
[15] | Ginhoux F, Tacke F, Angeli V, et al. Langerhans cells arise from monocytes in vivo[J]. Nat Immunol, 2006,7(3):265⁃273. doi: 10.1038/ni1307. |
[16] | Seré K, Baek JH, Ober⁃Blöbaum J, et al. Two distinct types of Langerhans cells populate the skin during steady state and inflammation[J]. Immunity, 2012,37(5):905⁃916. doi: 10.1016/j.immuni.2012.07.019. |
[17] | McCully ML, Kouzeli A, Moser B. Peripheral tissue chemokines: homeostatic control of immune surveillance T Cells[J]. Trends Immunol, 2018,39(9):734⁃747. doi: 10.1016/j.it.2018.06.003. |
[18] | Ferrer IR, West HC, Henderson S, et al. A wave of monocytes is recruited to replenish the long⁃term Langerhans cell network after immune injury[J]. Sci Immunol, 2019,4(38):eaax8704. doi: 10.1126/sciimmunol.aax8704. |
[19] | Milne P, Bigley V, Gunawan M, et al. CD1c+ blood dendritic cells have Langerhans cell potential[J]. Blood, 2015,125(3):470⁃473. doi: 10.1182/blood⁃2014⁃08⁃593582. |
[20] | Martínez⁃Cingolani C, Grandclaudon M, Jeanmougin M, et al. Human blood BDCA⁃1 dendritic cells differentiate into Langerhans⁃like cells with thymic stromal lymphopoietin and TGF⁃β[J]. Blood, 2014,124(15):2411⁃2420. doi: 10.1182/blood⁃2014⁃04⁃568311. |
[21] | Picarda G, Chéneau C, Humbert JM, et al. Functional Langerin high⁃expressing Langerhans⁃like cells can arise from CD14 high CD16⁃ human blood monocytes in serum⁃free condition[J]. J Immunol, 2016,196(9):3716⁃3728. doi: 10.4049/jimmunol.150 1304. |
[22] | Bobr A, Igyarto BZ, Haley KM, et al. Autocrine/paracrine TGF⁃β1 inhibits Langerhans cell migration[J]. Proc Natl Acad Sci U S A, 2012,109(26):10492⁃10497. doi: 10.1073/pnas.1119178109. |
[23] | Brand A, Diener N, Zahner SP, et al. E⁃Cadherin is dispensable to maintain Langerhans cells in the epidermis[J]. J Invest Dermatol, 2020,140(1):132⁃142.e3. doi: 10.1016/j.jid.2019.06. 132. |
[24] | Xiao C, Zhu Z, Sun S, et al. Activation of Langerhans cells promotes the inflammation in imiquimod⁃induced psoriasis⁃like dermatitis[J]. J Dermatol Sci, 2017,85(3):170⁃177. doi: 10. 1016/j.jdermsci.2016.12.003. |
[25] | Mohammed J, Beura LK, Bobr A, et al. Stromal cells control the epithelial residence of DC and memory T cells by regulated activation of TGF⁃β[J]. Nat Immunol, 2016,17(4):414⁃421. doi: 10.1038/ni.3396. |
[26] | Lopez MJ, Seyed⁃Razavi Y, Jamali A, et al. The chemokine receptor CXCR4 mediates recruitment of CD11c+ conventional dendritic cells into the inflamed murine cornea[J]. Invest Ophthalmol Vis Sci, 2018,59(13):5671⁃5681. doi: 10.1167/iovs. 18⁃25084. |
[27] | Russo E, Teijeira A, Vaahtomeri K, et al. Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels[J]. Cell Rep, 2016,14(7):1723⁃1734. doi: 10.1016/j.celrep.2016.01.048. |
[28] | Kissenpfennig A, Henri S, Dubois B, et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells[J]. Immunity, 2005,22(5):643⁃654. doi: 10. 1016/j.immuni.2005.04.004. |
[29] | Martini E, Wikén M, Cheuk S, et al. Dynamic changes in resident and infiltrating epidermal dendritic cells in active and resolved psoriasis[J]. J Invest Dermatol, 2017,137(4):865⁃873. doi: 10.1016/j.jid.2016.11.033. |
[30] | Shaw FL, Cumberbatch M, Kleyn CE, et al. Langerhans cell mobilization distinguishes between early⁃onset and late⁃onset psoriasis[J]. J Invest Dermatol, 2010,130(7):1940⁃1942. doi: 10.1038/jid.2010.57. |
[31] | Eaton LH, Mellody KT, Pilkington SM, et al. Impaired Langerhans cell migration in psoriasis is due to an altered keratinocyte phenotype induced by interleukin⁃17[J]. Br J Dermatol, 2018,178(6):1364⁃1372. doi: 10.1111/bjd.16172. |
[32] | Eaton LH, Dearman RJ, Kimber I, et al. Keratinocytes derived from late⁃onset⁃psoriasis skin do not impair Langerhans cell migration[J]. Br J Dermatol, 2018,179(5):1208⁃1209. doi: 10. 1111/bjd.16896. |
[33] | Shaw FL, Mellody KT, Ogden S, et al. Treatment⁃related restoration of Langerhans cell migration in psoriasis[J]. J Invest Dermatol, 2014,134(1):268⁃271. doi: 10.1038/jid.2013.289. |
[34] | Shipman WD, Chyou S, Ramanathan A, et al. A protective Langerhans cell⁃keratinocyte axis that is dysfunctional in photosensitivity[J]. Sci Transl Med, 2018,10(454):eaap9527. doi: 10.1126/ scitranslmed.aap9527. |
[35] | Raaby L, Rosada C, Langkilde A, et al. Langerhans cell markers CD1a and CD207 are the most rapidly responding genes in lesional psoriatic skin following adalimumab treatment[J]. Exp Dermatol, 2017,26(9):804⁃810. doi: 10.1111/exd.13304. |
[36] | Hawkes JE, Gudjonsson JE, Ward NL. The snowballing literature on imiquimod⁃induced skin inflammation in mice: a critical appraisal[J]. J Invest Dermatol, 2017,137(3):546⁃549. doi: 10.1016/j.jid.2016.10.024. |
[37] | Sweeney CM, Russell SE, Malara A, et al. Human ß⁃defensin 3 and its mouse ortholog murine ß⁃defensin 14 activate Langerhans cells and exacerbate psoriasis⁃like skin inflammation in mice[J]. J Invest Dermatol, 2016,136(3):723⁃727. doi: 10.1016/j.jid.2015.12.011. |
[38] | Wohn C, Ober⁃Blöbaum JL, Haak S, et al. Langerin(neg) conventional dendritic cells produce IL⁃23 to drive psoriatic plaque formation in mice[J]. Proc Natl Acad Sci U S A, 2013,110(26):10723⁃10728. doi: 10.1073/pnas.1307569110. |
[39] | Yoshiki R, Kabashima K, Honda T, et al. IL⁃23 from Langerhans cells is required for the development of imiquimod⁃induced psoriasis⁃like dermatitis by induction of IL⁃17A⁃producing γδ T cells[J]. J Invest Dermatol, 2014,134(7):1912⁃1921. doi: 10. 1038/jid.2014.98. |
[40] | Glitzner E, Korosec A, Brunner PM, et al. Specific roles for dendritic cell subsets during initiation and progression of psoriasis[J]. EMBO Mol Med, 2014,6(10):1312⁃1327. doi: 10. 15252/emmm.201404114. |
[41] | Moos S, Mohebiany AN, Waisman A, et al. Imiquimod⁃induced psoriasis in mice depends on the il⁃17 signaling of keratinocytes[J]. J Invest Dermatol, 2019,139(5):1110⁃1117. doi: 10.1016/j.jid.2019.01.006. |
[42] | Singh TP, Zhang HH, Borek I, et al. Monocyte⁃derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis⁃like inflammation[J]. Nat Commun, 2016,7:13581. doi: 10.1038/ncomms13581. |
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