黑素核在黑素转运与降解中的作用

doi:10.35541/cjd.20190198

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (8): 658-660.doi: 10.35541/cjd.20190198

黑素核在黑素转运与降解中的作用

耿清伟宋秀祖

杭州市第三人民医院皮肤科 310009

收稿日期:2019-01-07 修回日期:2019-07-05 发布日期:2020-07-31
通讯作者: 宋秀祖 E-mail:songxiuzu@sina.com
基金资助:
国家自然科学基金（81872517）；浙江省基础公益研究计划项目（LGF18H110001）；杭州市科技计划项目（20130733Q24）

Role of melanocores in melanin transfer and degradation

Geng Qingwei, Song Xiuzu

Department of Dermatology, The Third People′s Hospital of Hangzhou, Hangzhou 310009, China

Received:2019-01-07 Revised:2019-07-05 Published:2020-07-31
Contact: Song Xiuzu E-mail:songxiuzu@sina.com
Supported by:
National Natural Science Foundation of China（81872517）; Zhejiang Basic Public Welfare Research Project（LGF18H110001）; Hangzhou Science and Technology Planning Project（20130733Q24）

摘要/Abstract

摘要： 【摘要】黑素变化调节着皮肤颜色深浅。既往研究认为，黑素转运存在胞吐-胞吞、脱落-吞噬、细胞吞噬、膜融合四种途径，黑素小体是黑素转运的主要载体。新近研究显示，依赖于胞吐-胞吞途径的黑素核在黑素转运中具有重要作用。本文综述了黑素核转运中黑素细胞胞吐、角质形成细胞胞吞过程及转运后在角质形成细胞内的降解过程，为难治性色素性疾病提供新的治疗方向。

关键词: 黑色素小体, 黑素细胞, 角蛋白细胞, 胞吞作用, 黑素核

Abstract: 【Abstract】 Skin color is regulated by the change of melanin. Previous studies have shown that there are 4 modes of melanin transfer, including exocytosis-endocytosis, shedding-phagocytosis, cell phagocytosis and membrane fusion, and melanosomes are the main carrier of melanin transfer. Recent studies have shown that melanocores depending on the exocytosis-endocytosis pathway play an important role in melanin transfer. This review summarizes the melanocyte exocytosis and keratinocyte endocytosis processes in melanocore transfer, as well as the melanocore degradation process in keratinocytes after melanocore transfer, providing a new therapeutic direction for refractory pigmented diseases.

Key words: Melanosomes, Melanocytes, Keratinocytes, Endocytosis, Melanocore

耿清伟宋秀祖. 黑素核在黑素转运与降解中的作用[J]. 中华皮肤科杂志, 2020,53(8):658-660. doi:10.35541/cjd.20190198

Geng Qingwei, Song Xiuzu. Role of melanocores in melanin transfer and degradation[J]. Chinese Journal of Dermatology, 2020, 53(8): 658-660.doi:10.35541/cjd.20190198

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黑素核在黑素转运与降解中的作用

Role of melanocores in melanin transfer and degradation

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