中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (7): 622-628.doi: 10.35541/cjd.20220072
坚哲 张甲
收稿日期:
2022-01-26
修回日期:
2022-05-25
发布日期:
2022-07-05
通讯作者:
张甲
E-mail:362014063@qq.com
基金资助:
Jian Zhe, Zhang Jia
Received:
2022-01-26
Revised:
2022-05-25
Published:
2022-07-05
Contact:
Zhang Jia
E-mail:362014063@qq.com
Supported by:
摘要: 【摘要】 白癜风的病因及发病机制均未明确,动物模型是白癜风研究的重要工具。除传统的白癜风小鼠模型外,许多新模型逐渐建立,如表达表皮黑素细胞、黑素细胞反应性T细胞的小鼠模型、K14-SCF/h3TA2/HLA-A2三转基因(Vitesse鼠)小鼠模型、自身免疫诱导的小鼠模型、化学试剂诱导的小鼠模型等,这些模型与人白癜风高度相似,在可重复性和稳定性等方面都有不同程度提高,已成为研究白癜风发病机制、探索治疗靶点和评判疗效的良好模型。本文综述目前白癜风样小鼠脱色模型的研究进展,并分析存在的问题。
坚哲 张甲. 白癜风样小鼠皮肤脱色模型研究进展与思考[J]. 中华皮肤科杂志, 2022,55(7):622-628. doi:10.35541/cjd.20220072
Jian Zhe, Zhang Jia. Research progress and thinking in mouse models of vitiligo-like depigmentation[J]. Chinese Journal of Dermatology, 2022, 55(7): 622-628.doi:10.35541/cjd.20220072
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