中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (4): 376-379.doi: 10.35541/cjd.20200958

• 综述 • 上一篇    

瞬时受体电位通道在黑素细胞中的作用及相关疾病研究

陈怡1,宋秀祖2   

  1. 1浙江中医药大学附属杭州第三医院皮肤科,杭州  310009;2杭州市第三人民医院皮肤科,杭州  310009
  • 收稿日期:2020-09-29 修回日期:2021-06-16 发布日期:2023-03-31
  • 通讯作者: 宋秀祖 E-mail:songxiuzu@sina.com.cn
  • 基金资助:
    国家自然科学基金(81872517);浙江省基础公益研究计划项目(LGF18H110001)

Role of transient receptor potential channels in melanocytes and their related diseases

Chen Yi1, Song Xiuzu2   

  1. 1Department of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China; 2Department of Dermatology, Hangzhou Third People′s Hospital, Hangzhou 310009, China
  • Received:2020-09-29 Revised:2021-06-16 Published:2023-03-31
  • Contact: Song XiuZu E-mail:songxiuzu@sina.com.cn
  • Supported by:
    National Natural Science Foundation of China (81872517); Zhejiang Basic Public Welfare Research Project (LGF18H110001)

摘要: 【摘要】 瞬时受体电位通道(TRP通道)是位于细胞膜或细胞器膜上的一种特殊类型的非选择性阳离子通道家族,在黑素细胞中显著表达。本文综述近年来TRP通道在黑素细胞中的生理功能及其参与色素性皮肤病及黑素瘤病理过程的相关研究进展,为黑素相关疾病的防治提供新的理论基础。

关键词: 瞬时受体电位通道, 黑素细胞, 白癜风, 黑变病, 黑色素瘤

Abstract: 【Abstract】 Transient receptor potential (TRP) channels are a special type of non-selective cationic channel family located on the cell membrane or organelle membrane, and notably expressed in melanocytes. This review summarizes recent research progress in biological functions of TRP channels in melanocytes and their involvement in the pathological process of pigmented skin diseases and melanoma, so as to provide a new theoretical basis for the prevention and treatment of melanin-related diseases.

Key words: Transient receptor potential channels, Melanocyte, Vitiligo, Melanosis, Melanoma

引用本文

陈怡 宋秀祖. 瞬时受体电位通道在黑素细胞中的作用及相关疾病研究[J]. 中华皮肤科杂志, 2023,56(4):376-379. doi:10.35541/cjd.20200958

Chen Yi, Song Xiuzu. Role of transient receptor potential channels in melanocytes and their related diseases[J]. Chinese Journal of Dermatology, 2023, 56(4): 376-379.doi:10.35541/cjd.20200958