中华皮肤科杂志 ›› 2023, e20220368.doi: 10.35541/cjd.20220368

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抗黑素瘤分化相关基因5抗体阳性皮肌炎治疗进展

湛锦杉    玄秀云    曹娟梅    谌芳琪    黄长征   

  1. 华中科技大学同济医学院附属协和医院皮肤科,武汉  430022
  • 收稿日期:2022-05-23 修回日期:2022-12-20 发布日期:2023-07-20
  • 通讯作者: 黄长征 E-mail:hcz0501@126.com

Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis

Zhan Jinshan, Xuan Xiuyun, Cao Juanmei, Chen Fangqi, Huang Changzheng   

  1. Department of Dermatology, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2022-05-23 Revised:2022-12-20 Published:2023-07-20
  • Contact: Huang Changzheng E-mail:hcz0501@126.com

摘要: 【摘要】 抗黑素瘤分化相关基因5(MDA5)抗体阳性皮肌炎是皮肌炎的一种特殊类型,临床表现具有特征性,通常肌炎症状轻,易伴发急进性肺间质病变,预后差,发病机制尚不清楚,可能与遗传环境因素有关。本文总结近年来抗MDA5抗体阳性皮肌炎治疗进展,为临床治疗提供新思路。

关键词: 皮肌炎, 免疫抑制疗法, 黑色素瘤分化相关基因5, 抗黑色素瘤分化相关基因5抗体, 肺间质病变

Abstract: 【Abstract】 Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is a special type of dermatomyositis. It has characteristic clinical manifestations, mild myositis symptoms, and is prone to be accompanied by rapidly progressive interstitial lung disease, which indicates a poor prognosis. Its pathogenesis remains unclear, and may be related to genetic and environmental factors. This review summarizes progress in the treatment of anti-MDA5 antibody-positive dermatomyositis in recent years, in order to provide new ideas for its clinical treatment.

Key words: Dermatomyositis, Immunosuppressive therapy, Melanoma differentiation-associated gene 5, Anti-melanoma differentiation-associated gene 5 antibody, Interstitial lung disease

引用本文

湛锦杉 玄秀云 曹娟梅 谌芳琪 黄长征. 抗黑素瘤分化相关基因5抗体阳性皮肌炎治疗进展[J]. 中华皮肤科杂志, 2023,e20220368. doi:10.35541/cjd.20220368

Zhan Jinshan, Xuan Xiuyun, Cao Juanmei, Chen Fangqi, Huang Changzheng. Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis[J]. Chinese Journal of Dermatology,2023,e20220368. doi:10.35541/cjd.20220368