Abstract: MEI Xiang-lin, XIA Jian-xin, MU Yan, WANG Jing-yi, LI Xue, ZHU Wen-jing, LI Fu-qiu, JIN Xian-hua, YU Kai. Department of Dermatology, Second Hospital of Jilin University, Changchun 130041, China Corresponding author: XIA Jian-xin, Email: jianxinxia2003@tom.com 【Abstract】 Objective To evaluate the therapeutic effect of local application of an anti-fibroblast growth factor 10（FGF10） monoclonal antibody （MoAb） on a guinea pig model of psoriasis-like skin inflammation. Methods A model of psoriasis-like skin inflammation was established by applying 5% propranolol hydrochloride emulsion to the dorsal skin of ears of 45 guinea pigs, which were then classified into 5 groups: model group receiving no treatment, hydrocortisone butyrate group, high-, medium- and low-dose MoAb groups receiving topical treatment with hydrocortisone butyrate, anti-FGF10 MoAb of 0.188 g/L, 0.094 g/L and 0.063 g/L, respectively, twice daily. Nine guinea pigs receiving no propranolol challenge nor treatment served as the blank control group. The response of guinea pigs to propranolol hydrochloride emulsion and therapeutic agents, such as scratch behavior, hair status and skin status, was observed and recorded. After two weeks of treatment, all the guinea pigs were sacrificed, and skin samples were resected from the ears followed by the evaluation of Baker score, measurement of epidermal thickness, and enumeration of mononuclear cells. SPSS 13.0 software was used for data processing. Baker score was compared by rank sum test, mononuclear cell count and epidermal thickness by analysis of variance. Pairwise comparisons were carried out by the least significant difference （LSD） procedure. Results The number of mononuclear cells was similar between the high-dose MoAb group and blank control group （t = 0.77, P > 0.05）, but higher in the other treatment groups than in the high-dose MoAb group and blank control group （all P < 0.05）. Increased epidermal thickness was observed in the three MoAb groups compared with the hydrocortisone butyrate group （all P < 0.05）, while there was no statistical difference between the three MoAb groups （all P > 0.05）. Conclusions The anti-FGF10 MoAb obviously attenuates the pathological changes, affects the proliferation of keratinocytes, and markedly suppresses the inflammation, in the psoriasis-like skin model in guinea pigs.