Abstract: 【Abstract】 Chronic spontaneous urticaria （CSU） is a clinically common and therapeutically challenging chronic skin condition that significantly impairs patients' quality of life. With the increase in understanding of the pathogenesis of CSU, there has been a notable advancement in treatment strategies. The goals of treatment have shifted from symptomatic control to personalized precision medicine, comprehensive disease management, and enhancement of patients' quality of life. This article summarizes the latest advances in the subtyping, assessment, management strategies, and disease-modifying concepts of CSU, aiming to provide a new perspective for improving its clinical management.

Key words: Urticaria, Chronic spontaneous urticaria, Phenotype, Endotype, Patient-reported outcome measures, Biomarkers, Disease modification