遏制梅毒传播：新形势与新策略

doi:10.35541/cjd.20230729

Abstract

Abstract: 【Abstract】 Syphilis is one of the major sexually transmitted diseases prevalent in China currently, and the number of reported cases of syphilis has always been at the forefront of those of the Class B notifiable infectious diseases. Significant achievements have been made in syphilis prevention and control since the implementation of the “National Programme for Prevention and Control of Syphilis in China （2010 - 2020）” in 2010. However, the incidence of latent syphilis has continued to rise and some other problems have emerged, indicating that the situation of syphilis prevention and control is still grim. In the future, innovative strategies should be explored in areas such as health education and intervention, screening and standardized treatment of latent syphilis, as well as management of sexual partners, in order to cope with the new situation of syphilis transmission.

Key words: Syphilis, Syphilis, latent, Preventive health services, Contact tracing, Therapy, New situation, New strategies

Wang Qianqiu, Zheng Xiaoli, Du Fangzhi, Zhang Xu. Stop syphilis transmission: new situation and new strategies[J]. Chinese Journal of Dermatology, 2024, 57(3): 209-212.doi:10.35541/cjd.20230729

References ［40］

［1］	岳晓丽, 龚向东, 李婧, 等. 2014—2019年中国梅毒流行趋势与特征分析［J］. 中华皮肤科杂志, 2021, 54（8）: 668⁃672. doi: 10.35541/cjd.20210098.
［2］	WHO. Global health sector strategies on，respectively，HIV，viral hepatitis and sexually transmitted infections for the period 2022-2030［M］. Geneva: World Health Organization. 2022.
［3］	Chen XS, Jiang TT, Yin YP, et al. The past 70 years in control of syphilis in China: elimination and responses to resurgence ［J］. Int J Dermatol Venereol, 2020,3（4）:193⁃197. doi: 10.1097/JD9.0000000000000134.
［4］	龚向东，岳晓丽，滕菲，等. 2000—2013年中国梅毒流行特征与趋势分析［J］. 中华皮肤科杂志, 2014,47（5）:310⁃315.
［5］	陈祥生, 曹宁校, 王千秋, 等. 我国梅毒预防与控制：10年规划及成效［J］. 中国艾滋病性病, 2022,28（9）:1001⁃1004. doi: 10.13419/j.cnki.aids.2022.09.01.
［6］	Xie T, Wang G, Sun Q. Prevalence and predictors of syphilis in female sex workers in eastern China: findings from six consecutive cross⁃sectional surveys［J］. J Multidiscip Healthc, 2021,14:853⁃860. doi: 10.2147/JMDH.S305492.
［7］	杨银梅, 沈雅利, 李十月, 等. 中国大陆地区大学生性行为发生情况meta分析［J］. 中国公共卫生, 2018,34（1）:142⁃147. doi: 10.11847/zgggws1113830.
［8］	刘进权, 寇彩霞, 胡文龙, 等. 中国老年性病发病趋势及临床特点［J］. 皮肤科学通报, 2019,36（4）:460⁃465.
［9］	Xiao GY, Peng B, Hu Y, et al. Characteristics influencing high⁃risk sexual behaviours in elderly men［J］. Int J STD AIDS, 2019,30（4）:353⁃361. doi: 10.1177/0956462418804652.
［10］	杜方智, 郑志菊, 张栩, 等. 长沙市男男性行为者HIV和梅毒感染现状及影响因素分析［J］. 中国艾滋病性病, 2021,27（2）:132⁃136. doi: 10.13419/j.cnki.aids.2021.02.05.
［11］	马小剑, 江蓉, 丁子珺, 等. 2014—2019年扬州市男男性行为人群人类免疫缺陷病毒梅毒及丙型肝炎检测结果分析［J］. 实用医技杂志, 2021,28（11）:1341⁃1342. doi: 10.19522/j.cnki. 1671⁃5098.2021.11.024.
［12］	张祖样, 肖民扬, 宋丽军, 等. 2016⁃2018年云南省男男性行为者梅毒阳性率及影响因素分析［J］. 中国艾滋病性病, 2020, 26（5）: 526⁃9. doi: 10.1177/0956462418804652.
［13］	周艳君, 陈洁, 张静航, 等. 2011—2019年湖南省男男性行为人群哨点HIV、梅毒感染状况及性行为特征趋势分析［J］. 实用预防医学, 2023, 30（6）: 641⁃646. doi:10.3969/j.issn.1006⁃3110.2023.06.001.
［14］	陈禹衡, 刘晓燕, 史灵恩, 等. 2016⁃2021年江苏省不同流动性暗娼人群艾滋病及其他性传播疾病感染因素分析［J］. 疾病监测, 2023,38（6）:670⁃675. doi: 10.3784/jbjc.202302280070.
［15］	马娜, 张琬悦, 杨朝军, 等. 云南省曲靖市暗娼人群艾滋病、性病感染状况及生殖道沙眼衣原体感染影响因素分析［J］. 皮肤病与性病, 2022,44（1）:1⁃4. doi：10.3969/j.issn.1002⁃1310. 2022.01.001.
［16］	杨朝军, 马艳玲, 陈敏, 等. 昆明市暗娼人群中HIV梅毒淋球菌和生殖道沙眼衣原体感染的调查［J］. 中国艾滋病性病, 2020,26（10）:1110⁃1112,1115. doi: 10.13419/j.cnki.aids.2020. 10.21.
［17］	杨庆伟, 马婕萸, 熊燕. 云南省某市暗娼人群梅毒感染状况及影响因素分析［J］. 中国健康教育, 2021,37（3）:268⁃271. doi: 10.16168/j.cnki.issn.1002⁃9982.2021.03.017.
［18］	Hu M, Xu C, Wang J. Spatiotemporal analysis of men who have sex with men in mainland China: social app capture⁃recapture method［J］. JMIR Mhealth Uhealth, 2020,8（1）:e14800. doi: 10.2196/14800.
［19］	Berendes S, Gubijev A, French R, et al. A qualitative study exploring experiences of the safetxt digital health intervention to reduce sexually transmitted infections in young people in the UK［J］. BMJ Open, 2023,13（10）:e072701. doi: 10.1136/bmjopen⁃2023⁃072701.
［20］	李冰华, 黄洁英, 陆莉金, 等. 微视频健康教育模式提高隐性梅毒患者疾病认知和遵医治疗依从性的应用效果［J］. 临床护理杂志, 2023,22（1）:20⁃23. doi: 10.3969/j.issn.1671⁃8933.2023.01.006.
［21］	Wang C, Li X, Wang Y, et al. Syphilis self⁃testing among female sex workers in China: implications for expanding syphilis screening［J］. Front Public Health, 2022,10:744240. doi: 10.3389/fpubh.2022.744240.
［22］	Adamson PC, Loeffelholz MJ, Klausner JD. Point⁃of⁃care testing for sexually transmitted infections: a review of recent developments［J］. Arch Pathol Lab Med, 2020,144（11）:1344⁃1351. doi: 10.5858/arpa.2020⁃0118⁃RA.
［23］	Towns JM, Tieosapjaroen W, Mello MB, et al. The role of syphilis self⁃testing as an additional syphilis testing approach in key populations: a systematic review and meta⁃analysis［J］. Lancet Public Health, 2023,8（9）:e726⁃e734. doi: 10.1016/S2468⁃2667（23）00128⁃7.
［24］	Wu D, Zhou Y, Yang N, et al. Social media⁃based secondary distribution of human immunodeficiency virus/syphilis self⁃testing among Chinese men who have sex with men［J］. Clin Infect Dis, 2021,73（7）:e2251⁃e2257. doi: 10.1093/cid/ciaa825.
［25］	Mitjà O, Suñer C, Giacani L, et al. Treatment of bacterial sexually transmitted infections in Europe: gonorrhoea, mycoplasma genitalium, and syphilis［J］. Lancet Reg Health Eur, 2023,34:100737. doi: 10.1016/j.lanepe.2023.100737.
［26］	王千秋, 刘全忠, 徐金华, 等. 性传播疾病临床诊疗与防治指南［M］. 2版. 上海: 上海科学技术出版社, 2020.
［27］	Clark JL, Segura ER, Oldenburg CE, et al. Traditional and web⁃based technologies to improve partner notification following syphilis diagnosis among men who have sex with men in Lima, Peru: pilot randomized controlled trial［J］. J Med Internet Res. 2018,20（7）:e232. doi: 10.2196/jmir.9821.
［28］	Iturrieta⁃Guaita NG, Temple⁃Smith MJ, Tomnay J. Using electronic communication technologies for improving syphilis partner notification in Chile: healthcare providers′ perspectives ⁃ a qualitative case study［J］. Sex Health, 2019,16（4）:377⁃382. doi: 10.1071/SH19007.
［29］	Shrestha R, Maviglia F, Altice FL, et al. Mobile health technology use and the acceptability of an mHealth Platform for HIV prevention among men who have sex with men in Malaysia: cross⁃sectional respondent⁃driven sampling survey［J］. J Med Internet Res, 2022,24（7）:e36917. doi: 10.2196/36917.
［30］	Zamanpour A, Grennan T, Ablona A, et al. Treatment and partner notification outcomes for clients diagnosed with chlamydia and gonorrhea through GetCheckedOnline compared with sexually transmitted infection clinics in British Columbia, Canada［J］. Sex Transm Dis, 2023,50（2）:86⁃91. doi: 10.1097/OLQ.0000000000001735.
［31］	Folke T, Menon⁃Johansson AS. An evaluation of digital partner notification tool engagement and impact for patients diagnosed with gonorrhea and syphilis［J］. Sex Transm Dis, 2022,49（12）:815⁃821. doi: 10.1097/OLQ.0000000000001707.
［32］	Rodríguez I, Noda AA, Bosshard PP, et al. Anti⁃treponema pallidum IgA response as a potential diagnostic marker of syphilis［J］. Clin Microbiol Infect, 2023,29（12）:1603.e1⁃1603.e4. doi: 10.1016/j.cmi.2023.08.015.
［33］	Zondag H, van Dam AP, Bosch J, et al. Timely diagnosis of incubating syphilis infections using Treponema pallidum transcription⁃mediated amplification assay［J］. Clin Infect Dis, 2023,77（12）:1717⁃1722. doi: 10.1093/cid/ciad455.
［34］	Cohen J. Antibiotic after sex could help curb infections［J］. Science, 2022,377（6605）:459. doi: 10.1126/science.ade1303.
［35］	Gökengin D, Noori T, Alemany A, et al. Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe［J］. Lancet Reg Health Eur, 2023,34:100738. doi: 10.1016/j.lanepe.2023.100738.
［36］	Peters RPH, McIntyre JA, Garrett N, et al. Doxycycline post⁃exposure prophylaxis for sexually transmitted infections in South Africa ［J］. South Afr J HIV Med, 2023, 24（1）: 1510.doi: 10.1016/s1473⁃3099（17）30725⁃9.
［37］	Traeger MW, Mayer KH, Krakower DS, et al. Potential impact of doxycycline post⁃exposure prophylaxis prescribing strategies on incidence of bacterial sexually transmitted infections［J］. Clin Infect Dis, 2023. doi: 10.1093/cid/ciad488.
［38］	Liu D, He SM, Zhu XZ, et al. Molecular characterization based on MLST and ECDC typing schemes and antibiotic resistance analyses of Treponema pallidum subsp. pallidum in Xiamen, China ［J］. Front Cell Infect Microbiol, 2020, 10: 618747. doi: 10.1093/cid/ciad488.
［39］	Venter JME, Müller EE, Mahlangu MP, et al. Treponema pallidum macrolide resistance and molecular epidemiology in Southern Africa, 2008 to 2018［J］. J Clin Microbiol, 2021, 59（10）: e0238520. doi: 10.1038/s41598⁃022⁃20410⁃5.
［40］	Li S, Li W, Jin Y, et al. Advancements in the development of nucleic acid vaccines for syphilis prevention and control［J］. Hum Vaccin Immunother, 2023,19（2）:2234790. doi: 10.1080/21645515.2023.2234790.

[1]	Liu Yi, Qu Ying, Lei Wenzhi, Liu Xiaogang, Pan Weihua, Zhang Chao. Clinical efficacy of salt-packing therapy in the treatment of pyogenic granuloma [J]. Chinese Journal of Dermatology, 2024, 0(4): 20230553-e20230553.
[2]	Yang Yuting, Gu Guolin, Wu Minjuan, Sheng Zhijie, Li Jin, Mo Xingfan, Wu Minzhi, Xu Ping, . Application of serum fibronectin in combination with non-treponemal antibody testing in the exclusion of asymptomatic neurosyphilis among serofast syphilis patients: a preliminary study [J]. Chinese Journal of Dermatology, 2024, 57(3): 246-249.
[3]	Hospital for Skin Diseases, Chinese Academy of Medical Sciences, National Center for STD Control, Chinese Center for Disease Control and Prevention, Venereology Group, Chinese Society of Dermatology, Chinese Association Rehabilitation of Dermatology . Chinese expert consensus on the diagnosis and treatment of Mycoplasma genitalium infection （2024） [J]. Chinese Journal of Dermatology, 2024, 57(3): 201-208.
[4]	Xie Lin, Chen Rui, Niu Jianjun, Yang Tianci, . Comparison of diagnostic performance of novel neurosyphilis biomarkers UCH-L1, GFAP and NF-L versus traditional neurosyphilis indicators [J]. Chinese Journal of Dermatology, 2024, 57(3): 224-232.
[5]	Chen Nana, Li Zheng, Zhang Jie, Li Shishen, Li Wei. Early infection status among 147 cases of latent syphilis in Nanning city: a cross-sectional survey [J]. Chinese Journal of Dermatology, 2024, 57(3): 213-217.
[6]	Chinese Society of Dermatology, National Center for STD Control, Chinese Center for Disease Control and Prevention, China Dermatologist Association, Chinese Association Rehabilitation of Dermatology. Guideline for the diagnosis and treatment of Chlamydia trachomatis urogenital infection in China （2024） [J]. Chinese Journal of Dermatology, 2024, 57(3): 193-200.
[7]	Liu Jia, Gu Yinghua, He Xiaoning, . Treatment and disease burden of hereditary angioedema [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220205-e20220205.
[8]	Zong Yangyongyi, Ma Chujun, Su Zhonglan. Eczematization following the treatment of psoriasis with biological agents: pathogenesis and management [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220578-e20220578.
[9]	Yan Kexin, Xu Xiulian. Nanomedicine: a new strategy for the diagnosis and treatment of melanoma [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230109-e20230109.
[10]	Dai Yeqin, Song Xiuzu. Application of hair follicle transplantation and follicular cell suspension transplantation in the treatment of vitiligo [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230274-e0230274.
[11]	China Dermatologist Association, Chinese Society of Dermatology, Dermatology Branch of China International Exchange and Promotive Association for Medical and Health Care, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases. Expert consensus on the application and management of therapeutic drugs for atopic dermatitis （2024） [J]. Chinese Journal of Dermatology, 2024, 57(2): 97-108.
[12]	Na Jun, Li Ruoyu, Zhong Shaomin, Yang Li, Wu Yan. Diagnosis and treatment of rosacea in the real world: a survey on the current status [J]. Chinese Journal of Dermatology, 2024, 57(2): 127-133.
[13]	Ge Xinhong, Ma Yingdong, Jiao Yaning, Liu Lingling, Zhou Mei, Zi Wei, Li Bowen. Analysis of efficacy and safety of 532-nm picosecond laser in the treatment of early-stage facial seborrheic keratosis [J]. Chinese Journal of Dermatology, 2024, 0(2): 20230061-e20230061.
[14]	Yue Shuzhen, Shu Ye, Luo Yangyang, Li Keyao, Zhang Yuanyuan, Tang Jianping, Wei Zhu. Efficacy and safety of omalizumab in the treatment of chronic urticaria in children: a retrospective study [J]. Chinese Journal of Dermatology, 2024, 0(2): 20230006-e20230006.
[15]	Zeng Rui, Xu Xiulian. Narrow-band ultraviolet B phototherapy combined with other therapies for the treatment of vitiligo [J]. Chinese Journal of Dermatology, 2024, 57(1): 75-78.

Stop syphilis transmission: new situation and new strategies

PDF

Knowledge

Abstract

Cite this article

share this article

References ［40］

Related Articles 15

Metrics

Comments

Recommended 10